Strain hardening, avalanches, and strain softening in dense cross-linked actin networks

J.A. Åström, P.B.S. Kumar, I. Vattulainen, M.E.J. Karttunen

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    44 Citations (Scopus)
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    Abstract

    Actin filament networks enable the cytoskeleton to adjust to internal and external forcing. These dynamic networks can adapt to changes by dynamically adjusting their cross-links. Here, we model actin filaments as cross-linked elastic fibers of finite dimensions, with the cross-links being approximately 1 µm apart, and employ a full three-dimensional model to study their elastic properties by computer simulations. The results show compelling evidence that dense actin networks are characterized by (a) strain hardening without entropic elasticity, (b) avalanches of cross-link slippage leading to strain softening in the case of breakable cross-links, and (c) spontaneous formation of stress fibers in the case of dynamic cross-link formation and destruction.
    Original languageEnglish
    Pages (from-to)051913-1/6
    JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
    Volume77
    Issue number5
    DOIs
    Publication statusPublished - 2008

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