Stirring the Debate: How Mixing Influences Reproducibility and Efficiency in Synthetic Organic Chemistry

Jasper H.A. Schuurmans; Stefan D.A. Zondag; Arnab Chaudhuri; John van der Schaaf; Timothy Noël

doi:10.1021/acscentsci.5c01825

Stirring the Debate: How Mixing Influences Reproducibility and Efficiency in Synthetic Organic Chemistry

Jasper H.A. Schuurmans
, Stefan D.A. Zondag
, Arnab Chaudhuri
, John van der Schaaf (Corresponding author)
, Timothy Noël (Corresponding author-nrf)

EIRES Research

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

2 Downloads (Pure)

Abstract

Mixing is essential in chemical processes, ensuring the proximity and interaction of reactants. Recent reports suggest stirring may minimally affect some solution-phase organic reactions, but this oversimplifies mixing’s complexity. We discuss its principles, relevance to organic synthesis, and practical considerations for reproducibility and safety. Even if some reactions seem agitation-insensitive, mixing remains crucial for reproducibility, scalability, and industrial applications.

Original language	English
Pages (from-to)	7-13
Number of pages	7
Journal	ACS Central Science
Volume	12
Issue number	1
DOIs	https://doi.org/10.1021/acscentsci.5c01825
Publication status	Published - 28 Jan 2026

Bibliographical note

Publisher Copyright:
Published 2026 by American Chemical Society

Funding

All authors would like to thank NWO for financial support (19887, PhotoScale, Open Technology Program). J.H.A.S. and T.N. would like to thank the European Union’s Horizon research and innovation program CATART (101046836).

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Stirring the Debate: How Mixing Influences Reproducibility and Efficiency in Synthetic Organic Chemistry

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