Stimulus-responsive nanomotors based on gated enzyme-powered Janus Au-mesoporous silica nanoparticles for enhanced cargo delivery

Antoni Llopis-Lorente; Alba García-Fernández; Elena Lucena-Sánchez; Paula Díez; Félix Sancenón; Reynaldo Villalonga; Daniela A. Wilson; Ramón Martínez-Máñez

doi:10.1039/c9cc07250k

Stimulus-responsive nanomotors based on gated enzyme-powered Janus Au-mesoporous silica nanoparticles for enhanced cargo delivery

Antoni Llopis-Lorente
, Alba García-Fernández
, Elena Lucena-Sánchez
, Paula Díez
, Félix Sancenón
, Reynaldo Villalonga
, Daniela A. Wilson (Corresponding author)
, Ramón Martínez-Máñez (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

60 Citations (Scopus)

Abstract

Here we report functional stimulus-responsive nanomotors based on Janus Au-mesoporous silica nanoparticles capable of self-propelling via the biocatalytic conversion of chemical fuel, that read information from the environment (the presence of glutathione) and accordingly deliver a cargo.

Original language	English
Pages (from-to)	13164-13167
Number of pages	4
Journal	Chemical Communications, ChemComm
Volume	55
Issue number	87
DOIs	https://doi.org/10.1039/c9cc07250k
Publication status	Published - 29 Oct 2019
Externally published	Yes

Funding

The authors thank the Spanish Government (Projects MAT2015-64139-C4-1, AGL2015-70235-C2-2-R, CTQ2014-58989-P, CTQ2015-71936-REDT, CTQ2017-87954-P and RTI2018-100910-BC41) and the Generalitat Valencia (PROMETEO/2018/024) for support. The Comunidad de Madrid (IND2017/BMD-7642) is also gratefully acknowledged. D. A. W. acknowledges support from the Ministry of Education, Culture and Science (Gravitation program 024.001.035) and NWO Chemiche Wetenschappen VIDI grant 723.015.001.

Keywords

Antibiotics, Antineoplastic/chemistry
Biocatalysis
Catalase/chemistry
Cell Proliferation/drug effects
Doxorubicin/chemistry
Drug Carriers/chemistry
Drug Delivery Systems
Drug Screening Assays, Antitumor
Glutathione/chemistry
Gold/chemistry
HeLa Cells
Humans
Microscopy, Confocal
Microscopy, Fluorescence
Nanoparticles/chemistry
Particle Size
Porosity
Silicon Dioxide/chemistry
Surface Properties

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10.1039/c9cc07250k

Cite this

Llopis-Lorente, A., García-Fernández, A., Lucena-Sánchez, E., Díez, P., Sancenón, F., Villalonga, R., Wilson, D. A., & Martínez-Máñez, R. (2019). Stimulus-responsive nanomotors based on gated enzyme-powered Janus Au-mesoporous silica nanoparticles for enhanced cargo delivery. Chemical Communications, ChemComm, 55(87), 13164-13167. https://doi.org/10.1039/c9cc07250k

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title = "Stimulus-responsive nanomotors based on gated enzyme-powered Janus Au-mesoporous silica nanoparticles for enhanced cargo delivery",

abstract = "Here we report functional stimulus-responsive nanomotors based on Janus Au-mesoporous silica nanoparticles capable of self-propelling via the biocatalytic conversion of chemical fuel, that read information from the environment (the presence of glutathione) and accordingly deliver a cargo.",

keywords = "Antibiotics, Antineoplastic/chemistry, Biocatalysis, Catalase/chemistry, Cell Proliferation/drug effects, Doxorubicin/chemistry, Drug Carriers/chemistry, Drug Delivery Systems, Drug Screening Assays, Antitumor, Glutathione/chemistry, Gold/chemistry, HeLa Cells, Humans, Microscopy, Confocal, Microscopy, Fluorescence, Nanoparticles/chemistry, Particle Size, Porosity, Silicon Dioxide/chemistry, Surface Properties",

author = "Antoni Llopis-Lorente and Alba Garc{\'i}a-Fern{\'a}ndez and Elena Lucena-S{\'a}nchez and Paula D{\'i}ez and F{\'e}lix Sancen{\'o}n and Reynaldo Villalonga and Wilson, \{Daniela A.\} and Ram{\'o}n Mart{\'i}nez-M{\'a}{\~n}ez",

year = "2019",

month = oct,

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doi = "10.1039/c9cc07250k",

language = "English",

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journal = "Chemical Communications, ChemComm",

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Llopis-Lorente, A, García-Fernández, A, Lucena-Sánchez, E, Díez, P, Sancenón, F, Villalonga, R, Wilson, DA & Martínez-Máñez, R 2019, 'Stimulus-responsive nanomotors based on gated enzyme-powered Janus Au-mesoporous silica nanoparticles for enhanced cargo delivery', Chemical Communications, ChemComm, vol. 55, no. 87, pp. 13164-13167. https://doi.org/10.1039/c9cc07250k

Stimulus-responsive nanomotors based on gated enzyme-powered Janus Au-mesoporous silica nanoparticles for enhanced cargo delivery. / Llopis-Lorente, Antoni; García-Fernández, Alba; Lucena-Sánchez, Elena et al.
In: Chemical Communications, ChemComm, Vol. 55, No. 87, 29.10.2019, p. 13164-13167.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

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AU - Llopis-Lorente, Antoni

AU - García-Fernández, Alba

AU - Lucena-Sánchez, Elena

AU - Díez, Paula

AU - Sancenón, Félix

AU - Villalonga, Reynaldo

AU - Wilson, Daniela A.

AU - Martínez-Máñez, Ramón

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KW - Biocatalysis

KW - Catalase/chemistry

KW - Cell Proliferation/drug effects

KW - Doxorubicin/chemistry

KW - Drug Carriers/chemistry

KW - Drug Delivery Systems

KW - Drug Screening Assays, Antitumor

KW - Glutathione/chemistry

KW - Gold/chemistry

KW - HeLa Cells

KW - Humans

KW - Microscopy, Confocal

KW - Microscopy, Fluorescence

KW - Nanoparticles/chemistry

KW - Particle Size

KW - Porosity

KW - Silicon Dioxide/chemistry

KW - Surface Properties

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ER -

Stimulus-responsive nanomotors based on gated enzyme-powered Janus Au-mesoporous silica nanoparticles for enhanced cargo delivery

Abstract

Funding

Keywords

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