Stimuli responsive peptide conjugated polymer nanoparticles

J.R.I. Knoop, M. Geus, de, G.J.M. Habraken, C.E. Koning, H. Menzel, A. Heise

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)


We have investigated a novel approach to well-defined peptide-decorated cross-linked nanoparticles. The particles were obtained from well-defined poly(¿-benzyl-l-glutamate-b-styrene) block copolymers with active nitroxide end-groups by reaction with divinylbenzene (DVB). The block length ratio and the amount of cross-linker (DVB) were systematically varied. Molecular weights of the cross-linked particles up to 548000 g/mol with polydispersities around 1.5 were confirmed by size-exclusion chromatography. A clear dependence of the molecular weight from the block length ratio and the amount of cross-linker was observed. This was confirmed by dynamic light scattering results revealing the formation of nanoparticles up to 21 nm in size. The core-shell structure was evident from the TEM micrographs. Further deprotection of the peptide shell yielded water-soluble pH-responsive nanoparticles with a poly(l-glutamic acid) shell and a polystyrene core. Cryo-TEM micrographs confirmed the presence of individual core-shell particles in the aqueous solution.
Original languageEnglish
Pages (from-to)4126-4132
Issue number9
Publication statusPublished - 2010


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