State and history of heart tissue preparation for proton microprobe elemental analysis at the Eindhoven Cyclotron Laboratory

J.A. Quaedackers; P.H.A. Mutsaers; J.J.M. de Goeij; M.J.A. Voigt, de; G.J. Vusse, van der

doi:10.1016/S0168-583X(99)00502-9

State and history of heart tissue preparation for proton microprobe elemental analysis at the Eindhoven Cyclotron Laboratory

J.A. Quaedackers, P.H.A. Mutsaers, J.J.M. de Goeij, M.J.A. Voigt, de, G.J. Vusse, van der

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

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Abstract

Proton microprobe techniques are useful in investigating ischemia-reperfusion induced ion shifts between cardiac muscle cells and interstitial fluid. Preliminary results have shown that proper analysis of ion concentrations in various cardiac compartments is hampered by dislocation of elements during sample preparation. In this study the different stages of the preparation were evaluated as possible sources of artifacts. After improvements of the sample preparation procedure, sharp ion concentration gradients within heart tissue preparations were obtained, indicating no noticeable ion dislocation at the scale of the measurements.

Original language	English
Pages (from-to)	399-404
Number of pages	5
Journal	Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Volume	158
Issue number	1-4
DOIs	https://doi.org/10.1016/S0168-583X(99)00502-9
Publication status	Published - 1999

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Quaedackers, J. A., Mutsaers, P. H. A., de Goeij, J. J. M., Voigt, de, M. J. A., & Vusse, van der, G. J. (1999). State and history of heart tissue preparation for proton microprobe elemental analysis at the Eindhoven Cyclotron Laboratory. Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 158(1-4), 399-404. https://doi.org/10.1016/S0168-583X(99)00502-9

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title = "State and history of heart tissue preparation for proton microprobe elemental analysis at the Eindhoven Cyclotron Laboratory",

abstract = "Proton microprobe techniques are useful in investigating ischemia-reperfusion induced ion shifts between cardiac muscle cells and interstitial fluid. Preliminary results have shown that proper analysis of ion concentrations in various cardiac compartments is hampered by dislocation of elements during sample preparation. In this study the different stages of the preparation were evaluated as possible sources of artifacts. After improvements of the sample preparation procedure, sharp ion concentration gradients within heart tissue preparations were obtained, indicating no noticeable ion dislocation at the scale of the measurements.",

author = "J.A. Quaedackers and P.H.A. Mutsaers and {de Goeij}, J.J.M. and {Voigt, de}, M.J.A. and {Vusse, van der}, G.J.",

year = "1999",

doi = "10.1016/S0168-583X(99)00502-9",

language = "English",

volume = "158",

pages = "399--404",

journal = "Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms",

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Quaedackers, JA , Mutsaers, PHA, de Goeij, JJM, Voigt, de, MJA & Vusse, van der, GJ 1999, 'State and history of heart tissue preparation for proton microprobe elemental analysis at the Eindhoven Cyclotron Laboratory', Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, vol. 158, no. 1-4, pp. 399-404. https://doi.org/10.1016/S0168-583X(99)00502-9

State and history of heart tissue preparation for proton microprobe elemental analysis at the Eindhoven Cyclotron Laboratory. / Quaedackers, J.A.; Mutsaers, P.H.A.; de Goeij, J.J.M. et al.
In: Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, Vol. 158, No. 1-4, 1999, p. 399-404.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - State and history of heart tissue preparation for proton microprobe elemental analysis at the Eindhoven Cyclotron Laboratory

AU - Quaedackers, J.A.

AU - Mutsaers, P.H.A.

AU - de Goeij, J.J.M.

AU - Voigt, de, M.J.A.

AU - Vusse, van der, G.J.

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N2 - Proton microprobe techniques are useful in investigating ischemia-reperfusion induced ion shifts between cardiac muscle cells and interstitial fluid. Preliminary results have shown that proper analysis of ion concentrations in various cardiac compartments is hampered by dislocation of elements during sample preparation. In this study the different stages of the preparation were evaluated as possible sources of artifacts. After improvements of the sample preparation procedure, sharp ion concentration gradients within heart tissue preparations were obtained, indicating no noticeable ion dislocation at the scale of the measurements.

AB - Proton microprobe techniques are useful in investigating ischemia-reperfusion induced ion shifts between cardiac muscle cells and interstitial fluid. Preliminary results have shown that proper analysis of ion concentrations in various cardiac compartments is hampered by dislocation of elements during sample preparation. In this study the different stages of the preparation were evaluated as possible sources of artifacts. After improvements of the sample preparation procedure, sharp ion concentration gradients within heart tissue preparations were obtained, indicating no noticeable ion dislocation at the scale of the measurements.

U2 - 10.1016/S0168-583X(99)00502-9

DO - 10.1016/S0168-583X(99)00502-9

M3 - Article

SN - 0168-583X

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SP - 399

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JO - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

IS - 1-4

ER -

State and history of heart tissue preparation for proton microprobe elemental analysis at the Eindhoven Cyclotron Laboratory

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