TY - JOUR
T1 - Star polymers by cross-linking of linear poly(benzyl-L-glutamate) macromonomers via free-radical and RAFT polymerization. A simple route towards peptide-stabilized nanoparticles
AU - Audouin, F.
AU - Knoop, J.R.I.
AU - Huang, J.
AU - Heise, A.
PY - 2010
Y1 - 2010
N2 - Poly(benzyl-L-glutamate) (PBLG) macromonomers were synthesized by N-carboxyanhydride (NCA) polymerization initiated with 4-vinyl benzylamine. MALDI-ToF analysis confirmed the presence of styrenic end-groups in the PBLG. Free-radical and RAFT polymerization of the macromonomer in the presence of divinyl benzene produced star polymers of various molecular weights, polydispersity, and yield depending on the reaction conditions applied. The highest molecular weight (Mw) of 10,170,000 g/mol was obtained in a free-radical multibatch approach. It was shown that the PBLG star polymers can be deprotected to obtain poly(glutamic acid) star polymers, which form water soluble pH responsive nanoparticles.
AB - Poly(benzyl-L-glutamate) (PBLG) macromonomers were synthesized by N-carboxyanhydride (NCA) polymerization initiated with 4-vinyl benzylamine. MALDI-ToF analysis confirmed the presence of styrenic end-groups in the PBLG. Free-radical and RAFT polymerization of the macromonomer in the presence of divinyl benzene produced star polymers of various molecular weights, polydispersity, and yield depending on the reaction conditions applied. The highest molecular weight (Mw) of 10,170,000 g/mol was obtained in a free-radical multibatch approach. It was shown that the PBLG star polymers can be deprotected to obtain poly(glutamic acid) star polymers, which form water soluble pH responsive nanoparticles.
U2 - 10.1002/pola.24258
DO - 10.1002/pola.24258
M3 - Article
SN - 0887-624X
VL - 48
SP - 4602
EP - 4610
JO - Journal of Polymer Science, Part A: Polymer Chemistry
JF - Journal of Polymer Science, Part A: Polymer Chemistry
IS - 20
ER -