Standardization of fractional flow reserve measurements

G.G. Toth, N.P. Johnson, A. Jeremias, M. Pellicano, P. Vranckx, W.F. Fearon, E. Barbato, M.J. Kern, N.H.J. Pijls, B. De Bruyne

Research output: Contribution to journalReview articlepeer-review

139 Citations (Scopus)
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Pressure wire–based fractional flow reserve is considered the standard of reference for evaluation of the ischemic potential of coronary stenoses and the expected benefit from revascularization. Accordingly, its application in daily practice or for research purposes has to be as standardized as possible to avoid technical or operator-related artifacts in pressure recordings. This document proposes a standardized way of acquiring, recording, interpreting, and archiving the pressure tracings for daily practice and for the purpose of clinical research involving a core laboratory. Proposed standardized steps enhance the uniformity of clinical practices and data interpretation.

Original languageEnglish
Pages (from-to)742-753
Number of pages12
JournalJournal of the American College of Cardiology
Issue number7
Publication statusPublished - 1 Aug 2016


  • coronary artery disease
  • functional assessment
  • percutaneous coronary intervention


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