Stable helical 3-peptides in water via covalent bridging of side chains

E. Vaz, L. Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)


An on-bead cyclization protocol of ß3-peptides was developed, providing easy access to cyclic ß3-peptides. With this methodology, a small library of helical cyclic ß3-peptides was synthesized and investigated with CD spectroscopy. Covalent bridging of two side chains in ß3-peptides significantly stabilized their helical conformation in aqueous solutions and turned out to be superior to the previously described electrostatic interactions.
Original languageEnglish
Pages (from-to)4199-4202
JournalOrganic Letters
Issue number19
Publication statusPublished - 2006


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