SpotXplore is a plugin for Cytoscape for extraction and visualization of differentially expressed subnetworks (hotspots) from gene networks. The hotspot-based visualization approach enables interactive exploration of regulatory interactions in differentially expressed gene sets, and it allows a researcher to explore gene expression in direct relation to the affected cellular gene network. The hotspots provide a view beyond the commonly used metabolic pathways and gene ontologies.
Westenberg, M. A., Roerdink, J. B. T. M., Kuipers, O. P., & Hijum, van, S. A. F. T. (2010). SpotXplore: a Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks. Bioinformatics, 26(22), 2922-2923. https://doi.org/10.1093/bioinformatics/btq535