This study integrates spillover research of stress transferring from work to home and crossover research of strains transferring from one spouse to another. A spillover and crossover model was tested among 191 (couples of) dual-earner parents. For both males and females, it was hypothesized that (self-reported and partners' rating of) work-to-family interference (WFI) partially mediates the job demands-job exhaustion relationship, and fully mediates the job demands-life satisfaction relationship. Further, we hypothesized reciprocal crossover effects between both partners' job exhaustion and life satisfaction. The results of structural equation modeling analyses offered support for the mediating role of WFI although there were genders differences. In addition, we found a crossover path from females' exhaustion to males' exhaustion and from males' life satisfaction to their partners' life satisfaction. This implies that not only job-related strain, but also positive, context-free well-being may crossover among partners.