Abstract
Cryo-electron microscopy has evolved in an established approach to study the structure of bio-colloids. Recent developments in instrumentation and automation, often demanded by life sciences, made cryo-EM a general tool in colloid chemistry. Recently improved instrumentation for vitrification has resulted in reliable and reproducible preparation of specimen in water and other solvents. A dynamic approach, following processes in time is gaining importance and a time resolution up to 1 ms is expected to become general available. With improved instrumentation and automation 3D reconstructions by cryo-EM tomography are becoming routinely accessible. Tomography as such or in conjunction with time resolved microscopy is expected to give new insights in (macro)molecular assembly/disassembly mechanisms and thus become an essential tool in nano-chemistry.
| Original language | English |
|---|---|
| Pages (from-to) | 245-249 |
| Journal | Current Opinion in Colloid and Interface Science |
| Volume | 10 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 2005 |
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Center for Multiscale Electron Microscopy (CMEM)
Friedrich, H. (Manager), Bransen, M. (Education/research officer), Schmit, P. (Education/research officer), Schreur - Piet, I. (Other) & Spoelstra, A. (Education/research officer)
Facility/equipment: Research lab
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