Spatial and temporal resolution in cryo-electron microscopy : a scope for nano-chemistry

P.M. Frederik, N.A.J.M. Sommerdijk

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Cryo-electron microscopy has evolved in an established approach to study the structure of bio-colloids. Recent developments in instrumentation and automation, often demanded by life sciences, made cryo-EM a general tool in colloid chemistry. Recently improved instrumentation for vitrification has resulted in reliable and reproducible preparation of specimen in water and other solvents. A dynamic approach, following processes in time is gaining importance and a time resolution up to 1 ms is expected to become general available. With improved instrumentation and automation 3D reconstructions by cryo-EM tomography are becoming routinely accessible. Tomography as such or in conjunction with time resolved microscopy is expected to give new insights in (macro)molecular assembly/disassembly mechanisms and thus become an essential tool in nano-chemistry.
Original languageEnglish
Pages (from-to)245-249
JournalCurrent Opinion in Colloid and Interface Science
Issue number5-6
Publication statusPublished - 2005


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