Solubility of cannabinol in supercritical carbon dioxide

H. Perrotin-Brunel, M.J.E. Roosmalen, van, M.C. Kroon, J. Spronsen, van, G.J. Witkamp, C.J. Peters

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    23 Citations (Scopus)


    Cannabinol (CBN) is a decomposition product of the cannabinoid (-)-¿9-tetrahydrocannabinol (¿9-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10-4 to 4.16·10-4. CBN showed different behavior compared to ¿9-THC in terms of molar solubility. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) % absolute average relative deviation (AARD).
    Original languageEnglish
    Pages (from-to)3704-3707
    JournalJournal of Chemical and Engineering Data
    Issue number9
    Publication statusPublished - 2010


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