Solubility of cannabinol in supercritical carbon dioxide

H. Perrotin-Brunel, M.J.E. Roosmalen, van, M.C. Kroon, J. Spronsen, van, G.J. Witkamp, C.J. Peters

    Research output: Contribution to journalArticleAcademicpeer-review

    8 Citations (Scopus)

    Abstract

    Cannabinol (CBN) is a decomposition product of the cannabinoid (-)-¿9-tetrahydrocannabinol (¿9-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10-4 to 4.16·10-4. CBN showed different behavior compared to ¿9-THC in terms of molar solubility. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) % absolute average relative deviation (AARD).
    Original languageEnglish
    Pages (from-to)3704-3707
    JournalJournal of Chemical and Engineering Data
    Volume55
    Issue number9
    DOIs
    Publication statusPublished - 2010

    Fingerprint

    Cannabinol
    Carbon Dioxide
    Carbon dioxide
    Solubility
    Dronabinol
    Equations of state
    Cannabinoids
    Cannabis
    Decomposition

    Cite this

    Perrotin-Brunel, H., Roosmalen, van, M. J. E., Kroon, M. C., Spronsen, van, J., Witkamp, G. J., & Peters, C. J. (2010). Solubility of cannabinol in supercritical carbon dioxide. Journal of Chemical and Engineering Data, 55(9), 3704-3707. https://doi.org/10.1021/je100245n
    Perrotin-Brunel, H. ; Roosmalen, van, M.J.E. ; Kroon, M.C. ; Spronsen, van, J. ; Witkamp, G.J. ; Peters, C.J. / Solubility of cannabinol in supercritical carbon dioxide. In: Journal of Chemical and Engineering Data. 2010 ; Vol. 55, No. 9. pp. 3704-3707.
    @article{5dd291774d774517a8e136575d6f305b,
    title = "Solubility of cannabinol in supercritical carbon dioxide",
    abstract = "Cannabinol (CBN) is a decomposition product of the cannabinoid (-)-¿9-tetrahydrocannabinol (¿9-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10-4 to 4.16·10-4. CBN showed different behavior compared to ¿9-THC in terms of molar solubility. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) {\%} absolute average relative deviation (AARD).",
    author = "H. Perrotin-Brunel and {Roosmalen, van}, M.J.E. and M.C. Kroon and {Spronsen, van}, J. and G.J. Witkamp and C.J. Peters",
    year = "2010",
    doi = "10.1021/je100245n",
    language = "English",
    volume = "55",
    pages = "3704--3707",
    journal = "Journal of Chemical and Engineering Data",
    issn = "0021-9568",
    publisher = "American Chemical Society",
    number = "9",

    }

    Perrotin-Brunel, H, Roosmalen, van, MJE, Kroon, MC, Spronsen, van, J, Witkamp, GJ & Peters, CJ 2010, 'Solubility of cannabinol in supercritical carbon dioxide', Journal of Chemical and Engineering Data, vol. 55, no. 9, pp. 3704-3707. https://doi.org/10.1021/je100245n

    Solubility of cannabinol in supercritical carbon dioxide. / Perrotin-Brunel, H.; Roosmalen, van, M.J.E.; Kroon, M.C.; Spronsen, van, J.; Witkamp, G.J.; Peters, C.J.

    In: Journal of Chemical and Engineering Data, Vol. 55, No. 9, 2010, p. 3704-3707.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Solubility of cannabinol in supercritical carbon dioxide

    AU - Perrotin-Brunel, H.

    AU - Roosmalen, van, M.J.E.

    AU - Kroon, M.C.

    AU - Spronsen, van, J.

    AU - Witkamp, G.J.

    AU - Peters, C.J.

    PY - 2010

    Y1 - 2010

    N2 - Cannabinol (CBN) is a decomposition product of the cannabinoid (-)-¿9-tetrahydrocannabinol (¿9-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10-4 to 4.16·10-4. CBN showed different behavior compared to ¿9-THC in terms of molar solubility. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) % absolute average relative deviation (AARD).

    AB - Cannabinol (CBN) is a decomposition product of the cannabinoid (-)-¿9-tetrahydrocannabinol (¿9-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10-4 to 4.16·10-4. CBN showed different behavior compared to ¿9-THC in terms of molar solubility. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) % absolute average relative deviation (AARD).

    U2 - 10.1021/je100245n

    DO - 10.1021/je100245n

    M3 - Article

    VL - 55

    SP - 3704

    EP - 3707

    JO - Journal of Chemical and Engineering Data

    JF - Journal of Chemical and Engineering Data

    SN - 0021-9568

    IS - 9

    ER -

    Perrotin-Brunel H, Roosmalen, van MJE, Kroon MC, Spronsen, van J, Witkamp GJ, Peters CJ. Solubility of cannabinol in supercritical carbon dioxide. Journal of Chemical and Engineering Data. 2010;55(9):3704-3707. https://doi.org/10.1021/je100245n