Small-molecule Modulators of Protein-Protein Interactions: Focus on 14-3-3 PPIs

L. Iralde-Lorente, M. Botta, C. Ottmann

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Small-molecule modulation of protein-protein interactions (PPIs) is one of the most promising approaches for drug discovery and chemical biology. In this chapter we give a brief overview of some important concepts and examples with a focus on modulators of binding of the adaptor protein 14-3-3 to its multitude of targets, many of which are of high medical relevance.

Original languageEnglish
Title of host publicationProtein Degradation with New Chemical Modalities
Subtitle of host publicationSuccessful Strategies in Drug Discovery and Chemical Biology
EditorsSiddhartha Roy, Haian Fu
PublisherRoyal Society of Chemistry
Chapter10
Pages249-279
Number of pages31
Edition78
ISBN (Electronic)9781788011877, 9781788015479, 9781788016865, 9781788018012, 9781788018760
DOIs
Publication statusPublished - 2021

Publication series

NameRSC Drug Discovery Series
Number78
ISSN (Print)2041-3203
ISSN (Electronic)2041-3211

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