Sleep EEG characteristics associated with sleep onset misperception

Lieke Hermans (Corresponding author), Tim Leufkens, Merel van Gilst, Tim Weysen, M. Ross, P. Anderer, Sebastiaan Overeem, A. Vermeeren

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Study objective
To study sleep EEG characteristics associated with misperception of Sleep Onset Latency (SOL).

Methods
Data analysis was based on secondary analysis of standard in-lab polysomnographic recordings in 20 elderly people with insomnia and 21 elderly good sleepers. Parameters indicating sleep fragmentation, such as number of awakenings, wake after sleep onset (WASO) and percentage of NREM1 were extracted from the polsysomnogram, as well as spectral power, microarousals and sleep spindle index. The correlation between these parameters during the first sleep cycle and the amount of misperceived sleep was assessed in the insomnia group. Additionally, we made a model of the minimum duration that a sleep fragment at sleep onset should have in order to be perceived as sleep, and we fitted this model to subjective SOLs of both subject groups.

Results
Misperception of SOL was associated with increased percentage of NREM1 and more WASO during sleep cycle 1. For insomnia subjects, the best fit of modelled SOL with subjective SOL was found when assuming that sleep fragments shorter than 30 min at sleep onset were perceived as wake. The model indicated that healthy subjects are less sensitive to sleep interruptions and perceive fragments of 10 min or longer as sleep.

Conclusions
Our findings suggest that sleep onset misperception is related to sleep fragmentation at the beginning of the night. Moreover, we show that people with insomnia needed a longer duration of continuous sleep for the perception as such compared to controls. Further expanding the model could provide more detailed information about the underlying mechanisms of sleep misperception.
LanguageEnglish
Pages70-79
Number of pages10
JournalSleep Medicine
Volume57
Early online date6 Feb 2019
DOIs
StatePublished - May 2019

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Electroencephalography
Sleep
Sleep Initiation and Maintenance Disorders
Sleep Deprivation

Cite this

@article{5264ed307e1e4079a6d08d158703600a,
title = "Sleep EEG characteristics associated with sleep onset misperception",
abstract = "Study objectiveTo study sleep EEG characteristics associated with misperception of Sleep Onset Latency (SOL).MethodsData analysis was based on secondary analysis of standard in-lab polysomnographic recordings in 20 elderly people with insomnia and 21 elderly good sleepers. Parameters indicating sleep fragmentation, such as number of awakenings, wake after sleep onset (WASO) and percentage of NREM1 were extracted from the polsysomnogram, as well as spectral power, microarousals and sleep spindle index. The correlation between these parameters during the first sleep cycle and the amount of misperceived sleep was assessed in the insomnia group. Additionally, we made a model of the minimum duration that a sleep fragment at sleep onset should have in order to be perceived as sleep, and we fitted this model to subjective SOLs of both subject groups.ResultsMisperception of SOL was associated with increased percentage of NREM1 and more WASO during sleep cycle 1. For insomnia subjects, the best fit of modelled SOL with subjective SOL was found when assuming that sleep fragments shorter than 30 min at sleep onset were perceived as wake. The model indicated that healthy subjects are less sensitive to sleep interruptions and perceive fragments of 10 min or longer as sleep.ConclusionsOur findings suggest that sleep onset misperception is related to sleep fragmentation at the beginning of the night. Moreover, we show that people with insomnia needed a longer duration of continuous sleep for the perception as such compared to controls. Further expanding the model could provide more detailed information about the underlying mechanisms of sleep misperception.",
author = "Lieke Hermans and Tim Leufkens and {van Gilst}, Merel and Tim Weysen and M. Ross and P. Anderer and Sebastiaan Overeem and A. Vermeeren",
year = "2019",
month = "5",
doi = "10.1016/j.sleep.2019.01.031",
language = "English",
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pages = "70--79",
journal = "Sleep Medicine",
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Sleep EEG characteristics associated with sleep onset misperception. / Hermans, Lieke (Corresponding author); Leufkens, Tim; van Gilst, Merel; Weysen, Tim; Ross, M.; Anderer, P.; Overeem, Sebastiaan; Vermeeren, A.

In: Sleep Medicine, Vol. 57, 05.2019, p. 70-79.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Sleep EEG characteristics associated with sleep onset misperception

AU - Hermans,Lieke

AU - Leufkens,Tim

AU - van Gilst,Merel

AU - Weysen,Tim

AU - Ross,M.

AU - Anderer,P.

AU - Overeem,Sebastiaan

AU - Vermeeren,A.

PY - 2019/5

Y1 - 2019/5

N2 - Study objectiveTo study sleep EEG characteristics associated with misperception of Sleep Onset Latency (SOL).MethodsData analysis was based on secondary analysis of standard in-lab polysomnographic recordings in 20 elderly people with insomnia and 21 elderly good sleepers. Parameters indicating sleep fragmentation, such as number of awakenings, wake after sleep onset (WASO) and percentage of NREM1 were extracted from the polsysomnogram, as well as spectral power, microarousals and sleep spindle index. The correlation between these parameters during the first sleep cycle and the amount of misperceived sleep was assessed in the insomnia group. Additionally, we made a model of the minimum duration that a sleep fragment at sleep onset should have in order to be perceived as sleep, and we fitted this model to subjective SOLs of both subject groups.ResultsMisperception of SOL was associated with increased percentage of NREM1 and more WASO during sleep cycle 1. For insomnia subjects, the best fit of modelled SOL with subjective SOL was found when assuming that sleep fragments shorter than 30 min at sleep onset were perceived as wake. The model indicated that healthy subjects are less sensitive to sleep interruptions and perceive fragments of 10 min or longer as sleep.ConclusionsOur findings suggest that sleep onset misperception is related to sleep fragmentation at the beginning of the night. Moreover, we show that people with insomnia needed a longer duration of continuous sleep for the perception as such compared to controls. Further expanding the model could provide more detailed information about the underlying mechanisms of sleep misperception.

AB - Study objectiveTo study sleep EEG characteristics associated with misperception of Sleep Onset Latency (SOL).MethodsData analysis was based on secondary analysis of standard in-lab polysomnographic recordings in 20 elderly people with insomnia and 21 elderly good sleepers. Parameters indicating sleep fragmentation, such as number of awakenings, wake after sleep onset (WASO) and percentage of NREM1 were extracted from the polsysomnogram, as well as spectral power, microarousals and sleep spindle index. The correlation between these parameters during the first sleep cycle and the amount of misperceived sleep was assessed in the insomnia group. Additionally, we made a model of the minimum duration that a sleep fragment at sleep onset should have in order to be perceived as sleep, and we fitted this model to subjective SOLs of both subject groups.ResultsMisperception of SOL was associated with increased percentage of NREM1 and more WASO during sleep cycle 1. For insomnia subjects, the best fit of modelled SOL with subjective SOL was found when assuming that sleep fragments shorter than 30 min at sleep onset were perceived as wake. The model indicated that healthy subjects are less sensitive to sleep interruptions and perceive fragments of 10 min or longer as sleep.ConclusionsOur findings suggest that sleep onset misperception is related to sleep fragmentation at the beginning of the night. Moreover, we show that people with insomnia needed a longer duration of continuous sleep for the perception as such compared to controls. Further expanding the model could provide more detailed information about the underlying mechanisms of sleep misperception.

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DO - 10.1016/j.sleep.2019.01.031

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