Abstract
To study sleep EEG characteristics associated with misperception of Sleep Onset Latency (SOL).
Methods
Data analysis was based on secondary analysis of standard in-lab polysomnographic recordings in 20 elderly people with insomnia and 21 elderly good sleepers. Parameters indicating sleep fragmentation, such as number of awakenings, wake after sleep onset (WASO) and percentage of NREM1 were extracted from the polsysomnogram, as well as spectral power, microarousals and sleep spindle index. The correlation between these parameters during the first sleep cycle and the amount of misperceived sleep was assessed in the insomnia group. Additionally, we made a model of the minimum duration that a sleep fragment at sleep onset should have in order to be perceived as sleep, and we fitted this model to subjective SOLs of both subject groups.
Results
Misperception of SOL was associated with increased percentage of NREM1 and more WASO during sleep cycle 1. For insomnia subjects, the best fit of modelled SOL with subjective SOL was found when assuming that sleep fragments shorter than 30 min at sleep onset were perceived as wake. The model indicated that healthy subjects are less sensitive to sleep interruptions and perceive fragments of 10 min or longer as sleep.
Conclusions
Our findings suggest that sleep onset misperception is related to sleep fragmentation at the beginning of the night. Moreover, we show that people with insomnia needed a longer duration of continuous sleep for the perception as such compared to controls. Further expanding the model could provide more detailed information about the underlying mechanisms of sleep misperception.
| Original language | English |
|---|---|
| Pages (from-to) | 70-79 |
| Number of pages | 10 |
| Journal | Sleep Medicine |
| Volume | 57 |
| Early online date | 6 Feb 2019 |
| DOIs | |
| Publication status | Published - May 2019 |
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Sleep EEG characteristics associated with sleep onset misperception. / Hermans, Lieke (Corresponding author); Leufkens, Tim; van Gilst, Merel; Weysen, Tim; Ross, M.; Anderer, P.; Overeem, Sebastiaan; Vermeeren, A.
In: Sleep Medicine, Vol. 57, 05.2019, p. 70-79.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Sleep EEG characteristics associated with sleep onset misperception
AU - Hermans, Lieke
AU - Leufkens, Tim
AU - van Gilst, Merel
AU - Weysen, Tim
AU - Ross, M.
AU - Anderer, P.
AU - Overeem, Sebastiaan
AU - Vermeeren, A.
PY - 2019/5
Y1 - 2019/5
N2 - Study objectiveTo study sleep EEG characteristics associated with misperception of Sleep Onset Latency (SOL).MethodsData analysis was based on secondary analysis of standard in-lab polysomnographic recordings in 20 elderly people with insomnia and 21 elderly good sleepers. Parameters indicating sleep fragmentation, such as number of awakenings, wake after sleep onset (WASO) and percentage of NREM1 were extracted from the polsysomnogram, as well as spectral power, microarousals and sleep spindle index. The correlation between these parameters during the first sleep cycle and the amount of misperceived sleep was assessed in the insomnia group. Additionally, we made a model of the minimum duration that a sleep fragment at sleep onset should have in order to be perceived as sleep, and we fitted this model to subjective SOLs of both subject groups.ResultsMisperception of SOL was associated with increased percentage of NREM1 and more WASO during sleep cycle 1. For insomnia subjects, the best fit of modelled SOL with subjective SOL was found when assuming that sleep fragments shorter than 30 min at sleep onset were perceived as wake. The model indicated that healthy subjects are less sensitive to sleep interruptions and perceive fragments of 10 min or longer as sleep.ConclusionsOur findings suggest that sleep onset misperception is related to sleep fragmentation at the beginning of the night. Moreover, we show that people with insomnia needed a longer duration of continuous sleep for the perception as such compared to controls. Further expanding the model could provide more detailed information about the underlying mechanisms of sleep misperception.
AB - Study objectiveTo study sleep EEG characteristics associated with misperception of Sleep Onset Latency (SOL).MethodsData analysis was based on secondary analysis of standard in-lab polysomnographic recordings in 20 elderly people with insomnia and 21 elderly good sleepers. Parameters indicating sleep fragmentation, such as number of awakenings, wake after sleep onset (WASO) and percentage of NREM1 were extracted from the polsysomnogram, as well as spectral power, microarousals and sleep spindle index. The correlation between these parameters during the first sleep cycle and the amount of misperceived sleep was assessed in the insomnia group. Additionally, we made a model of the minimum duration that a sleep fragment at sleep onset should have in order to be perceived as sleep, and we fitted this model to subjective SOLs of both subject groups.ResultsMisperception of SOL was associated with increased percentage of NREM1 and more WASO during sleep cycle 1. For insomnia subjects, the best fit of modelled SOL with subjective SOL was found when assuming that sleep fragments shorter than 30 min at sleep onset were perceived as wake. The model indicated that healthy subjects are less sensitive to sleep interruptions and perceive fragments of 10 min or longer as sleep.ConclusionsOur findings suggest that sleep onset misperception is related to sleep fragmentation at the beginning of the night. Moreover, we show that people with insomnia needed a longer duration of continuous sleep for the perception as such compared to controls. Further expanding the model could provide more detailed information about the underlying mechanisms of sleep misperception.
U2 - 10.1016/j.sleep.2019.01.031
DO - 10.1016/j.sleep.2019.01.031
M3 - Article
C2 - 30897458
VL - 57
SP - 70
EP - 79
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
ER -