Abstract
Sleep disorders are common among patients with Parkinson's disease (PD). However, there are also reports of PD patients experiencing a beneficial effect of sleep. Upon awaking in the morning some patients experience good mobility, as if they are in an "on" state induced by medication, contrary to what would be expected after a night without medication. This intriguing phenomenon is known as sleep benefit. Here, we review the available research on sleep benefit in PD, describing its prevalence, clinical effects and determinants. We also discuss the possible mechanisms underlying sleep benefit, and the potential clinical applicability. Finally, we propose a new definition of sleep benefit to allow for improved standardization and homogeneity in future research. Important research targets include the development of objective measures of sleep benefit, as a basis for obtaining a better understanding of sleep benefit, its underlying mechanisms and its potential therapeutic application.
| Original language | English |
|---|---|
| Pages (from-to) | 654-659 |
| Number of pages | 6 |
| Journal | Parkinsonism & Related Disorders |
| Volume | 19 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2013 |
| Externally published | Yes |
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Keywords
- Humans
- Parkinsonian Disorders
- PubMed
- Sleep
- Sleep Disorders
Cite this
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"Sleep benefit" in Parkinson's disease : a systematic review. / van Gilst, M.; Bloem, B.R.; Overeem, S.
In: Parkinsonism & Related Disorders, Vol. 19, No. 7, 07.2013, p. 654-659.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - "Sleep benefit" in Parkinson's disease
T2 - a systematic review
AU - van Gilst, M.
AU - Bloem, B.R.
AU - Overeem, S.
N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.
PY - 2013/7
Y1 - 2013/7
N2 - Sleep disorders are common among patients with Parkinson's disease (PD). However, there are also reports of PD patients experiencing a beneficial effect of sleep. Upon awaking in the morning some patients experience good mobility, as if they are in an "on" state induced by medication, contrary to what would be expected after a night without medication. This intriguing phenomenon is known as sleep benefit. Here, we review the available research on sleep benefit in PD, describing its prevalence, clinical effects and determinants. We also discuss the possible mechanisms underlying sleep benefit, and the potential clinical applicability. Finally, we propose a new definition of sleep benefit to allow for improved standardization and homogeneity in future research. Important research targets include the development of objective measures of sleep benefit, as a basis for obtaining a better understanding of sleep benefit, its underlying mechanisms and its potential therapeutic application.
AB - Sleep disorders are common among patients with Parkinson's disease (PD). However, there are also reports of PD patients experiencing a beneficial effect of sleep. Upon awaking in the morning some patients experience good mobility, as if they are in an "on" state induced by medication, contrary to what would be expected after a night without medication. This intriguing phenomenon is known as sleep benefit. Here, we review the available research on sleep benefit in PD, describing its prevalence, clinical effects and determinants. We also discuss the possible mechanisms underlying sleep benefit, and the potential clinical applicability. Finally, we propose a new definition of sleep benefit to allow for improved standardization and homogeneity in future research. Important research targets include the development of objective measures of sleep benefit, as a basis for obtaining a better understanding of sleep benefit, its underlying mechanisms and its potential therapeutic application.
KW - Humans
KW - Parkinsonian Disorders
KW - PubMed
KW - Sleep
KW - Sleep Disorders
U2 - 10.1016/j.parkreldis.2013.03.014
DO - 10.1016/j.parkreldis.2013.03.014
M3 - Article
C2 - 23615667
VL - 19
SP - 654
EP - 659
JO - Parkinsonism & Related Disorders
JF - Parkinsonism & Related Disorders
SN - 1353-8020
IS - 7
ER -