"Sleep benefit" in Parkinson's disease: a systematic review

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Abstract

Sleep disorders are common among patients with Parkinson's disease (PD). However, there are also reports of PD patients experiencing a beneficial effect of sleep. Upon awaking in the morning some patients experience good mobility, as if they are in an "on" state induced by medication, contrary to what would be expected after a night without medication. This intriguing phenomenon is known as sleep benefit. Here, we review the available research on sleep benefit in PD, describing its prevalence, clinical effects and determinants. We also discuss the possible mechanisms underlying sleep benefit, and the potential clinical applicability. Finally, we propose a new definition of sleep benefit to allow for improved standardization and homogeneity in future research. Important research targets include the development of objective measures of sleep benefit, as a basis for obtaining a better understanding of sleep benefit, its underlying mechanisms and its potential therapeutic application.

Original languageEnglish
Pages (from-to)654-659
Number of pages6
JournalParkinsonism & Related Disorders
Volume19
Issue number7
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

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Parkinson Disease
Sleep
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Keywords

  • Humans
  • Parkinsonian Disorders
  • PubMed
  • Sleep
  • Sleep Disorders

Cite this

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title = "{"}Sleep benefit{"} in Parkinson's disease: a systematic review",
abstract = "Sleep disorders are common among patients with Parkinson's disease (PD). However, there are also reports of PD patients experiencing a beneficial effect of sleep. Upon awaking in the morning some patients experience good mobility, as if they are in an {"}on{"} state induced by medication, contrary to what would be expected after a night without medication. This intriguing phenomenon is known as sleep benefit. Here, we review the available research on sleep benefit in PD, describing its prevalence, clinical effects and determinants. We also discuss the possible mechanisms underlying sleep benefit, and the potential clinical applicability. Finally, we propose a new definition of sleep benefit to allow for improved standardization and homogeneity in future research. Important research targets include the development of objective measures of sleep benefit, as a basis for obtaining a better understanding of sleep benefit, its underlying mechanisms and its potential therapeutic application.",
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"Sleep benefit" in Parkinson's disease : a systematic review. / van Gilst, M.; Bloem, B.R.; Overeem, S.

In: Parkinsonism & Related Disorders, Vol. 19, No. 7, 07.2013, p. 654-659.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - "Sleep benefit" in Parkinson's disease

T2 - a systematic review

AU - van Gilst, M.

AU - Bloem, B.R.

AU - Overeem, S.

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2013/7

Y1 - 2013/7

N2 - Sleep disorders are common among patients with Parkinson's disease (PD). However, there are also reports of PD patients experiencing a beneficial effect of sleep. Upon awaking in the morning some patients experience good mobility, as if they are in an "on" state induced by medication, contrary to what would be expected after a night without medication. This intriguing phenomenon is known as sleep benefit. Here, we review the available research on sleep benefit in PD, describing its prevalence, clinical effects and determinants. We also discuss the possible mechanisms underlying sleep benefit, and the potential clinical applicability. Finally, we propose a new definition of sleep benefit to allow for improved standardization and homogeneity in future research. Important research targets include the development of objective measures of sleep benefit, as a basis for obtaining a better understanding of sleep benefit, its underlying mechanisms and its potential therapeutic application.

AB - Sleep disorders are common among patients with Parkinson's disease (PD). However, there are also reports of PD patients experiencing a beneficial effect of sleep. Upon awaking in the morning some patients experience good mobility, as if they are in an "on" state induced by medication, contrary to what would be expected after a night without medication. This intriguing phenomenon is known as sleep benefit. Here, we review the available research on sleep benefit in PD, describing its prevalence, clinical effects and determinants. We also discuss the possible mechanisms underlying sleep benefit, and the potential clinical applicability. Finally, we propose a new definition of sleep benefit to allow for improved standardization and homogeneity in future research. Important research targets include the development of objective measures of sleep benefit, as a basis for obtaining a better understanding of sleep benefit, its underlying mechanisms and its potential therapeutic application.

KW - Humans

KW - Parkinsonian Disorders

KW - PubMed

KW - Sleep

KW - Sleep Disorders

U2 - 10.1016/j.parkreldis.2013.03.014

DO - 10.1016/j.parkreldis.2013.03.014

M3 - Article

C2 - 23615667

VL - 19

SP - 654

EP - 659

JO - Parkinsonism & Related Disorders

JF - Parkinsonism & Related Disorders

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