Light-induced self-assembly leads to the folding of synthetic random-coil polymers into highly stable single-chain polymeric chiral nanoparticles (see picture; green: side chains, blue: phenyl rings, red: nitrophenyl leaving groups). The folding of the polymer was aided by heating and cooling steps.
Mes, T., Weegen, van der, R., Palmans, A. R. A., & Meijer, E. W. (2011). Single-chain polymeric nanoparticles by stepwise folding. Angewandte Chemie - International Edition, 50(22), 5085-5089. https://doi.org/10.1002/anie.201100104