Simulation of genetic networks modelled by piecewise deterministic Markov processes

S. Zeiser, U. Franz, O. Wittich, V. Liebscher

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)
1 Downloads (Pure)

Abstract

The authors propose piecewise deterministic Markov processes as an alternative approach to model gene regulatory networks. A hybrid simulation algorithm is presented and discussed, and several standard regulatory modules are analysed by numerical means. It is shown that despite of the partial simplification of the mesoscopic nature of regulatory networks such processes are suitable to reveal the intrinsic noise effects because of the low copy numbers of genes.
Original languageEnglish
Pages (from-to)113-135
JournalIET Systems Biology
Volume2
Issue number3
DOIs
Publication statusPublished - 2008

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