Simulating the First Breath: Design of the Respiratory Reflex in a Fetal Manikin

Tamara Hoveling; Juliette van Haren; Frank L.M. Delbressine

doi:10.1145/3502871.3502897

Simulating the First Breath: Design of the Respiratory Reflex in a Fetal Manikin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

2 Citations (Scopus)

7 Downloads (Pure)

Abstract

Extremely premature babies (24 to 28 weeks) have underdeveloped bodies, resulting in a survival rate of only 50-70%. To increase this rate, researchers around the globe are developing an artificial womb (AW), a safe environment that mimics the natural uterus, allowing the fetus to develop further. To successfully transfer the fetus from the natural uterus to the AW - while avoiding the respiratory reflex and thus neonatal transition - it is important that no air enters the lungs. To improve safety and minimize animal testing, the transfer procedure is first tested and trained using a fetal manikin simulation. To this end, the intent of this study was to perform a literature analysis to understand how the breathing reflex of a premature infant can be simulated in a fetal manikin. This study resulted in an overview of triggers known to initiate the respiration at birth and ways to detect these triggers, leading to a proposal for an electromechanical system. This proposal was incorporated into a realistic-looking prototype, which was subsequently evaluated with medical end users.

Original language	English
Title of host publication	International Conference on Biomedical and Bioinformatics Engineering
Publisher	Association for Computing Machinery, Inc.
Pages	163-169
Number of pages	7
ISBN (Print)	978-1-4503-8507-7
DOIs	https://doi.org/10.1145/3502871.3502897
Publication status	Published - 12 Nov 2021
Event	International Conference on Biomedical and Bioinformatics Engineering - Kyoto, Japan, Kyoto, Japan Duration: 12 Nov 2021 → 15 Nov 2021 http://www.icbbe.com

Conference

Conference	International Conference on Biomedical and Bioinformatics Engineering
Abbreviated title	ICBBE
Country/Territory	Japan
City	Kyoto
Period	12/11/21 → 15/11/21
Internet address	http://www.icbbe.com

Funding

This work was funded in part by the European Union via the Horizon 2020: Future Emerging Topics call (FET Open), grant EU863087, project PLS. MRI data upon which 3D reconstructions were made were provided by Radboudumc, department of Radiology and Nuclear Medicine, Nijmegen, The Netherlands.

Funders	Funder number
European Union's Horizon 2020 - Research and Innovation Framework Programme
European Commission
European Union's Horizon 2020 - Research and Innovation Framework Programme	863087

Keywords

Artificial Womb
Perinatal Life Support
Medical Simulation
Soft robotics
Actuator
Manikin
Gasp Reflex
Perinatal Life Support System
Fetal Manikin

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10.1145/3502871.3502897

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Cite this

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title = "Simulating the First Breath: Design of the Respiratory Reflex in a Fetal Manikin",

abstract = "Extremely premature babies (24 to 28 weeks) have underdeveloped bodies, resulting in a survival rate of only 50-70\%. To increase this rate, researchers around the globe are developing an artificial womb (AW), a safe environment that mimics the natural uterus, allowing the fetus to develop further. To successfully transfer the fetus from the natural uterus to the AW - while avoiding the respiratory reflex and thus neonatal transition - it is important that no air enters the lungs. To improve safety and minimize animal testing, the transfer procedure is first tested and trained using a fetal manikin simulation. To this end, the intent of this study was to perform a literature analysis to understand how the breathing reflex of a premature infant can be simulated in a fetal manikin. This study resulted in an overview of triggers known to initiate the respiration at birth and ways to detect these triggers, leading to a proposal for an electromechanical system. This proposal was incorporated into a realistic-looking prototype, which was subsequently evaluated with medical end users.",

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author = "Tamara Hoveling and \{van Haren\}, Juliette and Delbressine, \{Frank L.M.\}",

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booktitle = "International Conference on Biomedical and Bioinformatics Engineering",

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Hoveling, T, van Haren, J & Delbressine, FLM 2021, Simulating the First Breath: Design of the Respiratory Reflex in a Fetal Manikin. in International Conference on Biomedical and Bioinformatics Engineering. Association for Computing Machinery, Inc., pp. 163-169, International Conference on Biomedical and Bioinformatics Engineering, Kyoto, Japan, 12/11/21. https://doi.org/10.1145/3502871.3502897

Simulating the First Breath: Design of the Respiratory Reflex in a Fetal Manikin. / Hoveling, Tamara; van Haren, Juliette ; Delbressine, Frank L.M.
International Conference on Biomedical and Bioinformatics Engineering. Association for Computing Machinery, Inc., 2021. p. 163-169.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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N2 - Extremely premature babies (24 to 28 weeks) have underdeveloped bodies, resulting in a survival rate of only 50-70%. To increase this rate, researchers around the globe are developing an artificial womb (AW), a safe environment that mimics the natural uterus, allowing the fetus to develop further. To successfully transfer the fetus from the natural uterus to the AW - while avoiding the respiratory reflex and thus neonatal transition - it is important that no air enters the lungs. To improve safety and minimize animal testing, the transfer procedure is first tested and trained using a fetal manikin simulation. To this end, the intent of this study was to perform a literature analysis to understand how the breathing reflex of a premature infant can be simulated in a fetal manikin. This study resulted in an overview of triggers known to initiate the respiration at birth and ways to detect these triggers, leading to a proposal for an electromechanical system. This proposal was incorporated into a realistic-looking prototype, which was subsequently evaluated with medical end users.

AB - Extremely premature babies (24 to 28 weeks) have underdeveloped bodies, resulting in a survival rate of only 50-70%. To increase this rate, researchers around the globe are developing an artificial womb (AW), a safe environment that mimics the natural uterus, allowing the fetus to develop further. To successfully transfer the fetus from the natural uterus to the AW - while avoiding the respiratory reflex and thus neonatal transition - it is important that no air enters the lungs. To improve safety and minimize animal testing, the transfer procedure is first tested and trained using a fetal manikin simulation. To this end, the intent of this study was to perform a literature analysis to understand how the breathing reflex of a premature infant can be simulated in a fetal manikin. This study resulted in an overview of triggers known to initiate the respiration at birth and ways to detect these triggers, leading to a proposal for an electromechanical system. This proposal was incorporated into a realistic-looking prototype, which was subsequently evaluated with medical end users.

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PB - Association for Computing Machinery, Inc.

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ER -

Simulating the First Breath: Design of the Respiratory Reflex in a Fetal Manikin

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