Simulating cardiac mechanoenergetics in the left ventricle

M. Vendelin, P.H.M. Bovendeerd, V. Saks, J. Engelbrecht, M.G.J. Arts

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Distribution of myocardial perfusion and oxygen consumption within the cardiac wall is spatially heterogeneous. The cause of this heterogeneity is still unclear, but it is expected to be in close relation with the heterogeneity in mechanical function in the heart. In order to study the mechanical contraction and energy consumption by the cardiac wall, we developed a finite element model of the left ventricle with active properties described by the Huxley-type cross-bridge model. Here we present an overview of the developed model and the following simulation results obtained by the model. First, an important property of energy transformation from biochemical form to mechanical work in the cardiac muscle, the linear relationship between the oxygen consumption and the stress-strain area, is replicated by a cross-bridge model. Second, by using the developed cross-bridge model, the correlation between ejection fraction of the left ventricle and heterogeneity of sarcomere strain, developed stress and ATP consumption in the left ventricular wall is established. Third, an experimentally observed linear relationship between oxygen consumption and the pressure-volume area can be predicted theoretically from a linear relationship between the oxygen consumption and the stress-strain area.
Original languageEnglish
Title of host publicationProceedings of the 2nd International Workshop on Functional Imaging and Modeling of the Heart (FIMH), 5-6 June 2003, Lyon, France
EditorsI.E. Magnin, J. Montagnat, P. Clarysse
Place of PublicationBerlin, Germany
PublisherSpringer
Pages72-80
ISBN (Print)3-540-42861-5
DOIs
Publication statusPublished - 2003

Publication series

NameLecture Notes in Computer Science
Volume2674
ISSN (Print)0302-9743

Fingerprint Dive into the research topics of 'Simulating cardiac mechanoenergetics in the left ventricle'. Together they form a unique fingerprint.

Cite this