Distribution of myocardial perfusion and oxygen consumption within the cardiac wall is spatially heterogeneous. The cause of this heterogeneity is still unclear, but it is expected to be in close relation with the heterogeneity in mechanical function in the heart. In order to study the mechanical contraction and energy consumption by the cardiac wall, we developed a finite element model of the left ventricle with active properties described by the Huxley-type cross-bridge model. Here we present an overview of the developed model and the following simulation results obtained by the model. First, an important property of energy transformation from biochemical form to mechanical work in the cardiac muscle, the linear relationship between the oxygen consumption and the stress-strain area, is replicated by a cross-bridge model. Second, by using the developed cross-bridge model, the correlation between ejection fraction of the left ventricle and heterogeneity of sarcomere strain, developed stress and ATP consumption in the left ventricular wall is established. Third, an experimentally observed linear relationship between oxygen consumption and the pressure-volume area can be predicted theoretically from a linear relationship between the oxygen consumption and the stress-strain area.
|Title of host publication||Proceedings of the 2nd International Workshop on Functional Imaging and Modeling of the Heart (FIMH), 5-6 June 2003, Lyon, France|
|Editors||I.E. Magnin, J. Montagnat, P. Clarysse|
|Place of Publication||Berlin, Germany|
|Publication status||Published - 2003|
|Name||Lecture Notes in Computer Science|