Simple and stable transendothelial electrical resistance measurements in organs-on-chips

M.W. van der Helm, M. Odijk, J.P. Frimat, J.C.T. Eijkel, A. van den Berg, L.I. Segerink

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)

Abstract

Measuring transendothelial electrical resistance (TEER) is a popular way to monitor cellular barrier tightness in organs-on-chips. However, in these devices integrated electrodes often block sight on the cells and the measured part often includes fluid-filled channels with variable resistance. Therefore, we redesigned our blood-brain barrier on a chip model to be able to measure stable TEER with four electrodes positioned outside the culture area using a simple impedance measurement setup.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages771-773
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 1 Jan 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 25 Oct 201529 Oct 2015
Conference number: 19

Conference

Conference19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Abbreviated titleMicroTAS 2015
Country/TerritoryKorea, Republic of
CityGyeongju
Period25/10/1529/10/15

Keywords

  • Blood-brain barrier
  • Organs-on-chips
  • Transendothelial electrical resistance

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