Shedding the hydrophilic mantle of polymersomes

R.P. Brinkhuis; T.R. Visser; F.P.J.T. Rutjes; J.C.M. van Hest

doi:10.1039/c0py00316f

Shedding the hydrophilic mantle of polymersomes

R.P. Brinkhuis, T.R. Visser, F.P.J.T. Rutjes, J.C.M. van Hest

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Scopus)

Abstract

Block copolymers of polybutadiene-b-poly(ethylene glycol) were prepared in which both segments were coupled via an acid sensitive hydrazone moiety. Polymersomes that were subsequently formed showed a strong pH-dependent colloidal stability as a result of the pH sensitive removal of the PEG block. By mixing this stimulus responsive block polymer with an inert analogue it was possible to systematically remove percentages of PEG from the polymersome mantle. The minimum amount of surface PEGylation needed to retain stable polymersomes was found to be as low as five percent.

Original language	English
Pages (from-to)	550-552
Number of pages	3
Journal	Polymer Chemistry
Volume	2
Issue number	3
DOIs	https://doi.org/10.1039/c0py00316f
Publication status	Published - Mar 2011
Externally published	Yes

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author = "R.P. Brinkhuis and T.R. Visser and F.P.J.T. Rutjes and {van Hest}, J.C.M.",

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AU - Brinkhuis, R.P.

AU - Visser, T.R.

AU - Rutjes, F.P.J.T.

AU - van Hest, J.C.M.

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AB - Block copolymers of polybutadiene-b-poly(ethylene glycol) were prepared in which both segments were coupled via an acid sensitive hydrazone moiety. Polymersomes that were subsequently formed showed a strong pH-dependent colloidal stability as a result of the pH sensitive removal of the PEG block. By mixing this stimulus responsive block polymer with an inert analogue it was possible to systematically remove percentages of PEG from the polymersome mantle. The minimum amount of surface PEGylation needed to retain stable polymersomes was found to be as low as five percent.

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Shedding the hydrophilic mantle of polymersomes

Abstract

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