Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells

Sarita Kumari; Steven Vermeulen; Ben Van Der Veer; Aurélie Carlier; Jan De Boer; Deepa Subramanyam

doi:10.1089/ten.teb.2017.0468

Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells

Sarita Kumari, Steven Vermeulen, Ben Van Der Veer, Aurélie Carlier, Jan De Boer, Deepa Subramanyam

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

Abstract

Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency.

Original language	English
Pages (from-to)	255-266
Number of pages	12
Journal	Tissue Engineering. Part B, reviews
Volume	24
Issue number	4
DOIs	https://doi.org/10.1089/ten.teb.2017.0468
Publication status	Published - Aug 2018
Externally published	Yes

Keywords

embryonic stem cells
extracellular matrix
pluripotency
substratum

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10.1089/ten.teb.2017.0468

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title = "Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells",

abstract = "Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency.",

keywords = "embryonic stem cells, extracellular matrix, pluripotency, substratum",

author = "Sarita Kumari and Steven Vermeulen and {Van Der Veer}, Ben and Aur{\'e}lie Carlier and {De Boer}, Jan and Deepa Subramanyam",

year = "2018",

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T2 - Influence of Topographical Substratum Properties on Embryonic Stem Cells

AU - Kumari, Sarita

AU - Vermeulen, Steven

AU - Van Der Veer, Ben

AU - Carlier, Aurélie

AU - De Boer, Jan

AU - Subramanyam, Deepa

PY - 2018/8

Y1 - 2018/8

N2 - Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency.

AB - Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency.

KW - embryonic stem cells

KW - extracellular matrix

KW - pluripotency

KW - substratum

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U2 - 10.1089/ten.teb.2017.0468

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M3 - Review article

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SN - 1937-3368

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EP - 266

JO - Tissue Engineering. Part B, reviews

JF - Tissue Engineering. Part B, reviews

IS - 4

ER -

Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells

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Keywords

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