TY - JOUR
T1 - Shape-specific microfabricated particles for biomedical applications: a review
AU - Moore, Thomas L.
AU - Cook, Alexander B.
AU - Belotti, Elena
AU - Palomba, Roberto
AU - Manghnani, Purnima
AU - Spano, Raffaele
AU - Brahmachari, Sayanti
AU - Di Francesco, Martina
AU - Palange, Anna Lisa
AU - Di Mascolo, Daniele
AU - Decuzzi, Paolo
PY - 2022/8
Y1 - 2022/8
N2 - The storied history of controlled the release systems has evolved over time; from degradable drug-loaded sutures to monolithic zero-ordered release devices and nano-sized drug delivery formulations. Scientists have tuned the physico-chemical properties of these drug carriers to optimize their performance in biomedical/pharmaceutical applications. In particular, particle drug delivery systems at the micron size regime have been used since the 1980s. Recent advances in micro and nanofabrication techniques have enabled precise control of particle size and geometry–here we review the utility of microplates and discoidal polymeric particles for a range of pharmaceutical applications. Microplates are defined as micrometer scale polymeric local depot devices in cuboid form, while discoidal polymeric nanoconstructs are disk-shaped polymeric particles having a cross-sectional diameter in the micrometer range and a thickness in the hundreds of nanometer range. These versatile particles can be used to treat several pathologies such as cancer, inflammatory diseases and vascular diseases, by leveraging their size, shape, physical properties (e.g., stiffness), and component materials, to tune their functionality. This review highlights design and fabrication strategies for these particles, discusses their applications, and elaborates on emerging trends for their use in formulations.
AB - The storied history of controlled the release systems has evolved over time; from degradable drug-loaded sutures to monolithic zero-ordered release devices and nano-sized drug delivery formulations. Scientists have tuned the physico-chemical properties of these drug carriers to optimize their performance in biomedical/pharmaceutical applications. In particular, particle drug delivery systems at the micron size regime have been used since the 1980s. Recent advances in micro and nanofabrication techniques have enabled precise control of particle size and geometry–here we review the utility of microplates and discoidal polymeric particles for a range of pharmaceutical applications. Microplates are defined as micrometer scale polymeric local depot devices in cuboid form, while discoidal polymeric nanoconstructs are disk-shaped polymeric particles having a cross-sectional diameter in the micrometer range and a thickness in the hundreds of nanometer range. These versatile particles can be used to treat several pathologies such as cancer, inflammatory diseases and vascular diseases, by leveraging their size, shape, physical properties (e.g., stiffness), and component materials, to tune their functionality. This review highlights design and fabrication strategies for these particles, discusses their applications, and elaborates on emerging trends for their use in formulations.
KW - Drug Carriers/chemistry
KW - Drug Compounding
KW - Drug Delivery Systems/methods
KW - Particle Size
KW - Polymers/chemistry
UR - http://www.scopus.com/inward/record.url?scp=85126102304&partnerID=8YFLogxK
U2 - 10.1007/s13346-022-01143-4
DO - 10.1007/s13346-022-01143-4
M3 - Article
C2 - 35284984
SN - 2190-393X
VL - 12
SP - 2019
EP - 2037
JO - Drug Delivery and Translational Research
JF - Drug Delivery and Translational Research
IS - 8
ER -
