Shape modulation of squaramide-based supramolecular polymer nanoparticles

Victorio Saez Talens, D.M.M. Makurat, Tingxian Liu, Wei Dai, Clément Guibert, Willem E.M. Noteborn, Ilja K. Voets, Roxanne E. Kieltyka (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We report the synthesis and self-assembly of a library of squaramide-based bolaamphiphiles with variable hydrophobic and hydrophilic domain sizes, consisting of varied aliphatic chains (n = 2 to 12 methylene repeat units) and linear oligo(ethylene glycol) (m = 11 to 36 repeat units), to understand their effect on the formation of supramolecular polymer nanoparticles. Systematic variation of the hydrophobic chain length show that a minimum hydrophobic domain is required to shield the squaramide units from water when a constant hydrophilic domain is maintained for self-assembly. By contrast, significant increases to the hydrophilic chain length of the bolaamphiphile, while keeping the hydrophobic domain constant, results in a transition from fibrillar to spherical nanoscale objects with an alteration in the aggregation mode of the monomers likely due to steric constraints of the oligo(ethylene glycol) chains. By understanding the self-assembly space achievable for these squaramide-based bolaamphiphiles through examining the interplay between various monomer features, we show their distinct effects on the formation of self-assembled nanoparticles with possibilities to modulate their shape and size in water for future applications in the biomedical area.

Original languageEnglish
Pages (from-to)3146-3153
Number of pages8
JournalPolymer Chemistry
Volume10
Issue number23
DOIs
Publication statusPublished - 21 Jun 2019

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Nanoparticles
Self assembly
Polymers
Ethylene Glycol
Modulation
Ethylene glycol
Chain length
Monomers
Water
Self Report
Libraries
Agglomeration
bolaamphiphile
squaramide

Cite this

Saez Talens, V., Makurat, D. M. M., Liu, T., Dai, W., Guibert, C., Noteborn, W. E. M., ... Kieltyka, R. E. (2019). Shape modulation of squaramide-based supramolecular polymer nanoparticles. Polymer Chemistry, 10(23), 3146-3153. https://doi.org/10.1039/c9py00310j
Saez Talens, Victorio ; Makurat, D.M.M. ; Liu, Tingxian ; Dai, Wei ; Guibert, Clément ; Noteborn, Willem E.M. ; Voets, Ilja K. ; Kieltyka, Roxanne E. / Shape modulation of squaramide-based supramolecular polymer nanoparticles. In: Polymer Chemistry. 2019 ; Vol. 10, No. 23. pp. 3146-3153.
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Saez Talens, V, Makurat, DMM, Liu, T, Dai, W, Guibert, C, Noteborn, WEM, Voets, IK & Kieltyka, RE 2019, 'Shape modulation of squaramide-based supramolecular polymer nanoparticles', Polymer Chemistry, vol. 10, no. 23, pp. 3146-3153. https://doi.org/10.1039/c9py00310j

Shape modulation of squaramide-based supramolecular polymer nanoparticles. / Saez Talens, Victorio; Makurat, D.M.M.; Liu, Tingxian; Dai, Wei; Guibert, Clément; Noteborn, Willem E.M.; Voets, Ilja K.; Kieltyka, Roxanne E. (Corresponding author).

In: Polymer Chemistry, Vol. 10, No. 23, 21.06.2019, p. 3146-3153.

Research output: Contribution to journalArticleAcademicpeer-review

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Saez Talens V, Makurat DMM, Liu T, Dai W, Guibert C, Noteborn WEM et al. Shape modulation of squaramide-based supramolecular polymer nanoparticles. Polymer Chemistry. 2019 Jun 21;10(23):3146-3153. https://doi.org/10.1039/c9py00310j