Shape-induced asymmetric diffusion in dendritic spines allows efficient synaptic AMPA receptor trapping

R.P.T. Kusters, L.C. Kapitein, C.C. Hoogenraad, C. Storm

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)
1 Downloads (Pure)

Abstract

Dendritic spines are the primary postsynaptic sites of excitatory neurotransmission in the brain. They exhibit a remarkable morphological variety, ranging from thin protrusions, to stubby shapes, to bulbous mushroom shapes. The remodeling of spines is thought to regulate the strength of the synaptic connection, which depends vitally on the number and the spatial distribution of AMPA-type glutamate receptors (AMPARs). We present numerical and analytical analyses demonstrating that this shape strongly affects AMPAR diffusion. We report a pronounced suppression of the receptor exit rate out of spines with decreasing neck radius. Thus, mushroomlike spines become highly effective at retaining receptors in the spine head. Moreover, we show that the postsynaptic density further enhances receptor trapping, particularly in mushroomlike spines local exocytosis in the spine head, in contrast to release at the base, provides rapid and specific regulatory control of AMPAR concentration at synapses.
Original languageEnglish
Pages (from-to)2743-2750
Number of pages8
JournalBiophysical Journal
Volume105
Issue number12
DOIs
Publication statusPublished - 2013

Fingerprint

Dive into the research topics of 'Shape-induced asymmetric diffusion in dendritic spines allows efficient synaptic AMPA receptor trapping'. Together they form a unique fingerprint.

Cite this