Abstract
This article describes the sample prepn. and sepn. of three strongly basic central nervous system drugs by capillary electrochromatog. The sepn. was developed on Hypersil C8 MOS and Hypersil Ph stationary phases using acetonitrile as org. modifier together with mobile phase additives, ammonia, ethylenediamine, or 1,3-diaminopropane. A successful, fast sepn. after a simple derivatization procedure of the compd. was achieved on the Hypersil Ph stationary phase using ethylenediamine as mobile phase additive. The general approach to method development for complex mixts. is discussed. [on SciFinder (R)]
| Original language | English |
|---|---|
| Pages (from-to) | 43-52 |
| Number of pages | 10 |
| Journal | Journal of Separation Science |
| Volume | 26 |
| Issue number | 1/2 |
| DOIs | |
| Publication status | Published - 2003 |