Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array

R. Coehoorn (Inventor), M.W.J. Prins (Inventor)

Research output: PatentPatent publication

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Abstract

The present invention relates to a method and a device for magnetic detection of binding of biological molecules on a biochip. A magnetoresistive sensor device for measuring an areal density of magnetic nanoparticles on a micro-array, the magnetic nanoparticles (15) being directly or indirectly coupled to the target sample (11), is described. The magnetoresistive sensor device comprises a substrate (3) having attached thereto binding sites (9) able to selectively bind target sample (11), and a magnetoresistive sensor for detecting the magnetic field of the nanoparticles (15) coupled to the target sample. The magnetoresistive sensor comprises a plurality of magnetoresistive sensing elements (17, 19), the width and length dimensions of which are at least a factor 10 or more, preferably a factor 100 or more larger than the diameter of the nanoparticles (15). A corresponding method is described as well. [on SciFinder (R)]
Original languageEnglish
Patent numberWO/2003/054523
Publication statusPublished - 3 Jul 2003

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