@inbook{82367a1b779443b19ecfa4890b953d58,
title = "Semi-automated Computed Tomography Volumetry as a Proxy for Intracranial Pressure in Patients with Severe Traumatic Brain Injury: Clinical Feasibility Study",
abstract = "Introduction: Traumatic brain injury (TBI) is associated with high mortality due to intracranial pressure (ICP). Whether computed tomography (CT) scanning of the brain within the first 24 h is indicative of intracranial hypertension is largely unknown. We assessed the feasibility of semi-automated CT segmentation in comparison with invasive ICP measurements. Relevance: CT volumetry of the brain might provide ICP data when invasive monitoring is not possible or is undesirable. Methods: We identified 33 patients with TBI who received a CT scan at admission and ICP monitoring within 24 h. Semi-automated segmentation of CT images in Matlab yielded cerebrospinal fluid (CSF) and intracranial volume (ICV) data. The ratio CSF/ICV × 100 (expressed as a percentage) was used as a proxy for ICP. The association between invasive ICP and the CSF/ICV ratio was evaluated using a simple linear regression model and a mono-exponential function derived from previous research in animals. Results: ICP is moderately but significantly associated with the CSF/ICV ratio (r = −0.44, p = 0.01). The mono-exponential function provided a better fit of the relationship between ICP and the CSF/ICV ratio than the linear model. Conclusion: Our feasibility TBI data show that cross-sectional volumetric CT measures are associated with ICP. This non-invasive method can be used in future studies to monitor patients who are not candidates for invasive monitoring or to evaluate therapy effects objectively.",
keywords = "Brain imaging, Intracranial pressure, Traumatic brain injury, Volumetry, Intracranial Pressure, Cross-Sectional Studies, Humans, Brain Injuries, Traumatic/complications, Intracranial Hypertension/diagnostic imaging, Tomography, X-Ray Computed, Feasibility Studies",
author = "{van de Wijgert}, {Ilse H.} and Jansen, {Jacobus F.A.} and Jeanette Tas and Zeiler, {Fred A.} and Voorter, {Paulien H.M.} and {van Hal}, {Vera H.J.} and Aries, {Marcel J.}",
note = "Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG.",
year = "2021",
doi = "10.1007/978-3-030-59436-7_4",
language = "English",
isbn = "978-3-030-59438-1",
series = "Acta Neurochirurgica Supplement",
publisher = "Springer",
pages = "17--21",
editor = "Bart Depreitere",
booktitle = "Intracranial Pressure and Neuromonitoring XVII",
address = "Germany",
}