Self-healing biomaterials: from molecular concepts to clinical applications

Mani Diba, Sergio Spaans, Ke Ning, Bastiaan D. Ippel, Fang Yang, Bas Loomans, Patricia Y.W. Dankers, Sander C.G. Leeuwenburgh

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Abstract

Biomaterials are being applied in increasingly complex areas such as tissue engineering, bioprinting, and regenerative medicine. For these applications, challenging-or even contradictory-combinations of biomaterial properties are often required which cannot be met by conventional biomaterials. During the past decade, several new concepts have been developed to render biomaterials self-healing, thereby offering new opportunities to improve the functionality of traditional biomaterials in terms of their mechanical, handling, and biological properties. Consequently, various types of self-healing polymeric, ceramic, or composite biomaterials have been developed. Nevertheless, despite the rapid emergence of the field of self-healing biomaterials, this field of research has not been reviewed during the recent years. Therefore, this article provides a critical overview of recent progress in the field of self-healing biomaterials research by discussing both extrinsic and intrinsic self-healing systems. While the extrinsic self-healing section focuses on self-healing dental materials and orthopedic bone cements that rely on release of healing liquids from embedded microcapsules, the section on intrinsic self-healing materials mainly discusses concepts for self-healing of polymeric biomaterials that are either hydrated (hydrogels) or nonhydrated (e.g., films and coatings). Finally, benefits of the self-healing feature for biomaterials are discussed, and directions for future research and developments are outlined.

Original languageEnglish
Article number1800118
Number of pages21
JournalAdvanced Materials Interfaces
Volume5
Issue number17
DOIs
Publication statusPublished - 7 Sep 2018

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Keywords

  • Biomaterials
  • Extrinsic
  • Intrinsic
  • Self-healing
  • Self-repair

Cite this

Diba, M., Spaans, S., Ning, K., Ippel, B. D., Yang, F., Loomans, B., ... Leeuwenburgh, S. C. G. (2018). Self-healing biomaterials: from molecular concepts to clinical applications. Advanced Materials Interfaces, 5(17), [1800118]. https://doi.org/10.1002/admi.201800118