Self-assembling multivalency : supramolecular polymers assembled from monovalent mannose-labelled discotic molecules

K. Petkau - Milroy, L. Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
1 Downloads (Pure)

Abstract

Supramolecular synthesis, the "bottom-up" construction of higher-order structures from monomeric building blocks, represents a flexible approach for the generation of multivalent materials. Here, monovalent building blocks decorated with a single bioactive ligand were synthesized. In water, these supramolecular elements self-assemble into columnar polymers that display multiple ligands. The supramolecular effect on the binding affinity was evaluated by using an enzyme-linked lectin assay, and the self-assembled architecture exhibited a stronger inhibitory power than that of the monovalent bioactive ligand. This so-called self-assembling multivalency enables the rapid and flexible generation of multivalent polymers from monovalent building blocks.
Original languageEnglish
Pages (from-to)3470-3476
Number of pages7
JournalEuropean Journal of Organic Chemistry
Volume2013
Issue number17
DOIs
Publication statusPublished - 2013

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