Abstract
Supramolecular synthesis, the "bottom-up" construction of higher-order structures from monomeric building blocks, represents a flexible approach for the generation of multivalent materials. Here, monovalent building blocks decorated with a single bioactive ligand were synthesized. In water, these supramolecular elements self-assemble into columnar polymers that display multiple ligands. The supramolecular effect on the binding affinity was evaluated by using an enzyme-linked lectin assay, and the self-assembled architecture exhibited a stronger inhibitory power than that of the monovalent bioactive ligand. This so-called self-assembling multivalency enables the rapid and flexible generation of multivalent polymers from monovalent building blocks.
Original language | English |
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Pages (from-to) | 3470-3476 |
Number of pages | 7 |
Journal | European Journal of Organic Chemistry |
Volume | 2013 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2013 |