Self-assembled fluorescent organic nanoparticles for live cell imaging

I. Fischer, K. Petkau, Y.L. Dorland, A.P.H.J. Schenning, L. Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)
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Abstract

Fluorescent, cell-permeable, organic nanoparticles based on self-assembled p-conjugated oligomers with high absorption cross-sections and high quantum yields have been developed. The nanoparticles are generated with a tuneable density of amino groups for charge-mediated cellular uptake by a straightforward self-assembly protocol, which allows for control over size and toxicity. The results show that a single amino group per ten oligomers is sufficient to achieve cellular uptake. The non-toxic nanoparticles are suitable for both one- and two-photon cellular imaging and flow cytometry, and undergo very efficient cellular uptake.
Original languageEnglish
Pages (from-to)16646-16650
Number of pages5
JournalChemistry : A European Journal
Volume19
Issue number49
DOIs
Publication statusPublished - 2013

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