Self-assembled fluorescent organic nanoparticles for live cell imaging

I. Fischer, K. Petkau, Y.L. Dorland, A.P.H.J. Schenning, L. Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Fluorescent, cell-permeable, organic nanoparticles based on self-assembled p-conjugated oligomers with high absorption cross-sections and high quantum yields have been developed. The nanoparticles are generated with a tuneable density of amino groups for charge-mediated cellular uptake by a straightforward self-assembly protocol, which allows for control over size and toxicity. The results show that a single amino group per ten oligomers is sufficient to achieve cellular uptake. The non-toxic nanoparticles are suitable for both one- and two-photon cellular imaging and flow cytometry, and undergo very efficient cellular uptake.
Original languageEnglish
Pages (from-to)16646-16650
Number of pages5
JournalChemistry : A European Journal
Volume19
Issue number49
DOIs
Publication statusPublished - 2013

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Nanoparticles
Imaging techniques
Oligomers
Photons
Flow cytometry
Quantum yield
Self assembly
Toxicity

Cite this

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Self-assembled fluorescent organic nanoparticles for live cell imaging. / Fischer, I.; Petkau, K.; Dorland, Y.L.; Schenning, A.P.H.J.; Brunsveld, L.

In: Chemistry : A European Journal, Vol. 19, No. 49, 2013, p. 16646-16650.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Self-assembled fluorescent organic nanoparticles for live cell imaging

AU - Fischer, I.

AU - Petkau, K.

AU - Dorland, Y.L.

AU - Schenning, A.P.H.J.

AU - Brunsveld, L.

PY - 2013

Y1 - 2013

N2 - Fluorescent, cell-permeable, organic nanoparticles based on self-assembled p-conjugated oligomers with high absorption cross-sections and high quantum yields have been developed. The nanoparticles are generated with a tuneable density of amino groups for charge-mediated cellular uptake by a straightforward self-assembly protocol, which allows for control over size and toxicity. The results show that a single amino group per ten oligomers is sufficient to achieve cellular uptake. The non-toxic nanoparticles are suitable for both one- and two-photon cellular imaging and flow cytometry, and undergo very efficient cellular uptake.

AB - Fluorescent, cell-permeable, organic nanoparticles based on self-assembled p-conjugated oligomers with high absorption cross-sections and high quantum yields have been developed. The nanoparticles are generated with a tuneable density of amino groups for charge-mediated cellular uptake by a straightforward self-assembly protocol, which allows for control over size and toxicity. The results show that a single amino group per ten oligomers is sufficient to achieve cellular uptake. The non-toxic nanoparticles are suitable for both one- and two-photon cellular imaging and flow cytometry, and undergo very efficient cellular uptake.

U2 - 10.1002/chem.201302647

DO - 10.1002/chem.201302647

M3 - Article

C2 - 24281811

VL - 19

SP - 16646

EP - 16650

JO - Chemistry : A European Journal

JF - Chemistry : A European Journal

SN - 0947-6539

IS - 49

ER -