Abstract
A mild and selective C(sp3)−H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C−H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (−)-ambroxide, pregnenolone acetate, (+)-sclareolide, and artemisinin, exemplifies the utility of this new method.
| Original language | English |
|---|---|
| Pages (from-to) | 4078-4082 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 57 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 3 Apr 2018 |
Keywords
- aerobic oxidation
- C(sp)−H functionalization
- decatungstate
- flow chemistry
- photocatalysis
- C(sp )−H functionalization
- C(sp(3))-H functionalization
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Laudadio, G., Govaerts, S., Wang, Y., Ravelli, D., Koolman, H., Fagnoni, M., Djuric, S., & Noel, T. (2018). Selective C(sp3)−H aerobic oxidation enabled by decatungstate photocatalysis in flow. Angewandte Chemie - International Edition, 57(15), 4078-4082. https://doi.org/10.1002/anie.201800818