TY - JOUR
T1 - Selective C(sp3)−H aerobic oxidation enabled by decatungstate photocatalysis in flow
AU - Laudadio, G.
AU - Govaerts, S.
AU - Wang, Y.
AU - Ravelli, D.
AU - Koolman, H.
AU - Fagnoni, M.
AU - Djuric, S.
AU - Noel, T.
PY - 2018/4/3
Y1 - 2018/4/3
N2 - A mild and selective C(sp3)−H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C−H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (−)-ambroxide, pregnenolone acetate, (+)-sclareolide, and artemisinin, exemplifies the utility of this new method.
AB - A mild and selective C(sp3)−H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C−H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (−)-ambroxide, pregnenolone acetate, (+)-sclareolide, and artemisinin, exemplifies the utility of this new method.
KW - aerobic oxidation
KW - C(sp)−H functionalization
KW - decatungstate
KW - flow chemistry
KW - photocatalysis
KW - C(sp )−H functionalization
KW - C(sp(3))-H functionalization
UR - http://www.scopus.com/inward/record.url?scp=85043533429&partnerID=8YFLogxK
U2 - 10.1002/anie.201800818
DO - 10.1002/anie.201800818
M3 - Article
C2 - 29451725
VL - 57
SP - 4078
EP - 4082
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 0570-0833
IS - 15
ER -