Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial

Mohamed El Farissi; Daniëlle C.J. Keulards; Marcel van 't Veer; Jo M. Zelis; Colin Berry; Bernard de Bruyne; Thomas Engstrøm; Ole Fröbert; Zsolt Piroth; Keith G. Oldroyd; Pim A.L. Tonino; Nico H.J. Pijls; Luuk C. Otterspoor

doi:10.4244/EIJ-D-19-00471

Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial

Mohamed El Farissi (Corresponding author), Daniëlle C.J. Keulards, Marcel van 't Veer, Jo M. Zelis, Colin Berry, Bernard de Bruyne, Thomas Engstrøm, Ole Fröbert, Zsolt Piroth, Keith G. Oldroyd, Pim A.L. Tonino, Nico H.J. Pijls, Luuk C. Otterspoor

Cardiovascular Biomechanics

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes ¹. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury ². In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS ³. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI ⁴. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method. Methods STUDY OBJECTIVES The primary objective of the EURO-ICE trial is to evaluate the effect of selective intracoronary hypothermia (SIH) on IS.

Original language	English
Pages (from-to)	1444-1446
Number of pages	3
Journal	EuroIntervention
Volume	16
Issue number	17
DOIs	https://doi.org/10.4244/EIJ-D-19-00471
Publication status	Published - 20 Apr 2021

Funding

The EURO-ICE trial is an investigator-initiated trial without any commercial purpose or pursuit of profit by the sponsor of the study, Cathreine B.V. The trial is financed by a research grant from Abbott. Their support remains limited to funding only, with no influence on study design, data collection or analysis, or final manuscript publication.

Keywords

Abciximab
Angioplasty, Balloon, Coronary
Humans
Hypothermia
Percutaneous Coronary Intervention/adverse effects
ST Elevation Myocardial Infarction/diagnosis
Treatment Outcome

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10.4244/EIJ-D-19-00471

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El Farissi, M., Keulards, D. C. J., van 't Veer, M., Zelis, J. M., Berry, C., de Bruyne, B., Engstrøm, T., Fröbert, O., Piroth, Z., Oldroyd, K. G., Tonino, P. A. L., Pijls, N. H. J., & Otterspoor, L. C. (2021). Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial. EuroIntervention, 16(17), 1444-1446. https://doi.org/10.4244/EIJ-D-19-00471

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title = "Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial",

abstract = "In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes 1. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury 2. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS 3. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI 4. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method. Methods STUDY OBJECTIVES The primary objective of the EURO-ICE trial is to evaluate the effect of selective intracoronary hypothermia (SIH) on IS. ",

keywords = "Abciximab, Angioplasty, Balloon, Coronary, Humans, Hypothermia, Percutaneous Coronary Intervention/adverse effects, ST Elevation Myocardial Infarction/diagnosis, Treatment Outcome",

author = "\{El Farissi\}, Mohamed and Keulards, \{Dani{\"e}lle C.J.\} and \{van 't Veer\}, Marcel and Zelis, \{Jo M.\} and Colin Berry and \{de Bruyne\}, Bernard and Thomas Engstr{\o}m and Ole Fr{\"o}bert and Zsolt Piroth and Oldroyd, \{Keith G.\} and Tonino, \{Pim A.L.\} and Pijls, \{Nico H.J.\} and Otterspoor, \{Luuk C.\}",

year = "2021",

month = apr,

day = "20",

doi = "10.4244/EIJ-D-19-00471",

language = "English",

volume = "16",

pages = "1444--1446",

journal = "EuroIntervention",

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El Farissi, M, Keulards, DCJ, van 't Veer, M, Zelis, JM, Berry, C, de Bruyne, B, Engstrøm, T, Fröbert, O, Piroth, Z, Oldroyd, KG, Tonino, PAL, Pijls, NHJ & Otterspoor, LC 2021, 'Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial', EuroIntervention, vol. 16, no. 17, pp. 1444-1446. https://doi.org/10.4244/EIJ-D-19-00471

Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial. / El Farissi, Mohamed (Corresponding author); Keulards, Daniëlle C.J.; van 't Veer, Marcel et al.
In: EuroIntervention, Vol. 16, No. 17, 20.04.2021, p. 1444-1446.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction

T2 - rationale and design of the EURO-ICE Trial

AU - El Farissi, Mohamed

AU - Keulards, Daniëlle C.J.

AU - van 't Veer, Marcel

AU - Zelis, Jo M.

AU - Berry, Colin

AU - de Bruyne, Bernard

AU - Engstrøm, Thomas

AU - Fröbert, Ole

AU - Piroth, Zsolt

AU - Oldroyd, Keith G.

AU - Tonino, Pim A.L.

AU - Pijls, Nico H.J.

AU - Otterspoor, Luuk C.

PY - 2021/4/20

Y1 - 2021/4/20

N2 - In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes 1. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury 2. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS 3. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI 4. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method. Methods STUDY OBJECTIVES The primary objective of the EURO-ICE trial is to evaluate the effect of selective intracoronary hypothermia (SIH) on IS.

AB - In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes 1. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury 2. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS 3. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI 4. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method. Methods STUDY OBJECTIVES The primary objective of the EURO-ICE trial is to evaluate the effect of selective intracoronary hypothermia (SIH) on IS.

KW - Abciximab

KW - Angioplasty, Balloon, Coronary

KW - Humans

KW - Hypothermia

KW - Percutaneous Coronary Intervention/adverse effects

KW - ST Elevation Myocardial Infarction/diagnosis

KW - Treatment Outcome

U2 - 10.4244/EIJ-D-19-00471

DO - 10.4244/EIJ-D-19-00471

M3 - Article

C2 - 31498112

SN - 1774-024X

VL - 16

SP - 1444

EP - 1446

JO - EuroIntervention

JF - EuroIntervention

IS - 17

ER -

Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial

Abstract

Funding

Keywords

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