Abstract
In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes [1]. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury [2]. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS [3]. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI [4]. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method.
Original language | English |
---|---|
Pages (from-to) | 1190-1198 |
Journal | EuroIntervention |
Volume | 15 |
DOIs | |
Publication status | E-pub ahead of print - 10 Sep 2019 |