Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial

Mohamed El Farissi (Corresponding author), Daniëlle C.J. Keulards, Marcel van 't Veer, Jo M. Zelis, Colin Berry, Bernard de Bruyne, Thomas Engstrøm, Ole Fröbert, Zsolt Piroth, Keith G. Oldroyd, Pim A.L. Tonino, Nico H.J. Pijls, Luuk C. Otterspoor

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes [1]. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury [2]. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS [3]. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI [4]. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method.
Original languageEnglish
Pages (from-to)1190-1198
JournalEuroIntervention
Volume15
DOIs
Publication statusE-pub ahead of print - 10 Sep 2019

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