Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial

Mohamed El Farissi; Daniëlle C.J. Keulards; Marcel van 't Veer; Jo M. Zelis; Colin Berry; Bernard de Bruyne; Thomas Engstrøm; Ole Fröbert; Zsolt Piroth; Keith G. Oldroyd; Pim A.L. Tonino; Nico H.J. Pijls; Luuk C. Otterspoor

doi:10.4244/EIJ-D-19-00471

Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial

Mohamed El Farissi (Corresponding author), Daniëlle C.J. Keulards, Marcel van 't Veer, Jo M. Zelis, Colin Berry, Bernard de Bruyne, Thomas Engstrøm, Ole Fröbert, Zsolt Piroth, Keith G. Oldroyd, Pim A.L. Tonino, Nico H.J. Pijls, Luuk C. Otterspoor

Cardiovascular Biomechanics

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes [1]. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury [2]. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS [3]. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI [4]. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method.

Original language	English
Pages (from-to)	1190-1198
Journal	EuroIntervention
Volume	15
DOIs	https://doi.org/10.4244/EIJ-D-19-00471
Publication status	E-pub ahead of print - 10 Sep 2019

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El Farissi, M., Keulards, D. C. J., van 't Veer, M., Zelis, J. M., Berry, C., de Bruyne, B., Engstrøm, T., Fröbert, O., Piroth, Z., Oldroyd, K. G., Tonino, P. A. L., Pijls, N. H. J., & Otterspoor, L. C. (2019). Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial. EuroIntervention, 15, 1190-1198. https://doi.org/10.4244/EIJ-D-19-00471

El Farissi, Mohamed ; Keulards, Daniëlle C.J. ; van 't Veer, Marcel ; Zelis, Jo M. ; Berry, Colin ; de Bruyne, Bernard ; Engstrøm, Thomas ; Fröbert, Ole ; Piroth, Zsolt ; Oldroyd, Keith G. ; Tonino, Pim A.L. ; Pijls, Nico H.J. ; Otterspoor, Luuk C. / Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction : rationale and design of the EURO-ICE Trial. In: EuroIntervention. 2019 ; Vol. 15. pp. 1190-1198.

@article{02b5604fe2894db882bf055db41e5d86,

title = "Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial",

abstract = "In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes [1]. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury [2]. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS [3]. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI [4]. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method.",

author = "{El Farissi}, Mohamed and Keulards, {Dani{\"e}lle C.J.} and {van 't Veer}, Marcel and Zelis, {Jo M.} and Colin Berry and {de Bruyne}, Bernard and Thomas Engstr{\o}m and Ole Fr{\"o}bert and Zsolt Piroth and Oldroyd, {Keith G.} and Tonino, {Pim A.L.} and Pijls, {Nico H.J.} and Otterspoor, {Luuk C.}",

year = "2019",

month = sep,

day = "10",

doi = "10.4244/EIJ-D-19-00471",

language = "English",

volume = "15",

pages = "1190--1198",

journal = "EuroIntervention",

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El Farissi, M, Keulards, DCJ , van 't Veer, M , Zelis, JM, Berry, C, de Bruyne, B, Engstrøm, T, Fröbert, O, Piroth, Z, Oldroyd, KG, Tonino, PAL, Pijls, NHJ & Otterspoor, LC 2019, 'Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: rationale and design of the EURO-ICE Trial', EuroIntervention, vol. 15, pp. 1190-1198. https://doi.org/10.4244/EIJ-D-19-00471

Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction : rationale and design of the EURO-ICE Trial. / El Farissi, Mohamed (Corresponding author); Keulards, Daniëlle C.J.; van 't Veer, Marcel ; Zelis, Jo M.; Berry, Colin; de Bruyne, Bernard; Engstrøm, Thomas; Fröbert, Ole; Piroth, Zsolt; Oldroyd, Keith G.; Tonino, Pim A.L.; Pijls, Nico H.J.; Otterspoor, Luuk C.

In: EuroIntervention, Vol. 15, 10.09.2019, p. 1190-1198.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction

T2 - rationale and design of the EURO-ICE Trial

AU - El Farissi, Mohamed

AU - Keulards, Daniëlle C.J.

AU - van 't Veer, Marcel

AU - Zelis, Jo M.

AU - Berry, Colin

AU - de Bruyne, Bernard

AU - Engstrøm, Thomas

AU - Fröbert, Ole

AU - Piroth, Zsolt

AU - Oldroyd, Keith G.

AU - Tonino, Pim A.L.

AU - Pijls, Nico H.J.

AU - Otterspoor, Luuk C.

PY - 2019/9/10

Y1 - 2019/9/10

N2 - In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes [1]. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury [2]. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS [3]. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI [4]. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method.

AB - In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes [1]. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury [2]. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS [3]. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI [4]. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method.

UR - https://eurointervention.pcronline.com/article/selective-intracoronary-hypothermia-in-patients-with-st-elevation-myocardial-infarction-rationale-and-design-of-the-euro-ice-trial

U2 - 10.4244/EIJ-D-19-00471

DO - 10.4244/EIJ-D-19-00471

M3 - Article

C2 - 31498112

VL - 15

SP - 1190

EP - 1198

JO - EuroIntervention

JF - EuroIntervention

SN - 1774-024X

ER -