Screening as a strategy to drive regenerative medicine research

Steven Vermeulen, Jan de Boer (Corresponding author)

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

In the field of regenerative medicine, optimization of the parameters leading to a desirable outcome remains a huge challenge. Examples include protocols for the guided differentiation of pluripotent cells towards specialized and functional cell types, phenotypic maintenance of primary cells in cell culture, or engineering of materials for improved tissue interaction with medical implants. This challenge originates from the enormous design space for biomaterials, chemical and biochemical compounds, and incomplete knowledge of the guiding biological principles. To tackle this challenge, high-throughput platforms allow screening of multiple perturbations in one experimental setup. In this review, we provide an overview of screening platforms that are used in regenerative medicine. We discuss their fabrication techniques, and in silico tools to analyze the extensive data sets typically generated by these platforms.

Original languageEnglish
Pages (from-to)80-95
Number of pages16
JournalMethods
Volume190
Early online date9 Apr 2020
DOIs
Publication statusPublished - Jun 2021

Funding

SV acknowledges the financial support of the European Union’s Horizon 2020 Programme (H2020-MSCA- ITN-2015; Grant agreement 676338). We gratefully thank Urnaa Tuvshindorj for sharing a figure of a RGD adhesive island based high-throughput platform.

FundersFunder number
European Union 's Horizon 2020 - Research and Innovation Framework Programme
Marie Skłodowska‐Curie676338

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