Abstract
Inflammatory bowel disease (IBD) is characterized by increased levels of reactive oxygen species (ROS) in inflamed areas of the gastrointestinal tract and in circulating immune cells, providing novel opportunities for targeted drug delivery. In the recent experiments, oxidation-responsive polymeric nanostructures selectively degrade in the presence of H2O2. Based on these results, it is hypothesized that such degradation process can be triggered in a similar way by the incubation with stimulated monocytes isolated from patients with IBD. A first indication is given by a significant correlation between excessive ROS and degradation of micelles in monocytes isolated from healthy individuals after phorbol 12-myristate 13-acetate (PMA) stimulation. But even if the ROS-sensitive micelles are incubated with nonstimulated monocytes from patients with active IBD, a spontaneous degradation is observed in contrast to micelles incubated with monocytes from healthy donors. The findings indicate that the thioether-based micelles are indeed promising for selective drug release in the presence of activated immune cells.
| Original language | English |
|---|---|
| Article number | 2100482 |
| Number of pages | 6 |
| Journal | Macromolecular Bioscience |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2022 |
Bibliographical note
Funding Information:This work was financially supported by the DFG-funded Collaborative Research Centre PolyTarget (Project-ID: 316213987-SFB 1278, A05). Tony Bruns was supported by the German Research Foundation (CRC1382, Project-ID 403224013). Johannes C. Brendel further thanks the DFG for funding within the Emmy-Noether Programme (Project-ID: 358263073). Furthermore, the authors thank Stephanie Höppener for her support by performing the CryoTEM investigations at the electron microscopy facilities of the Jena Center for Soft Matter (JCSM), which were purchased with grants from the DFG and the European funds for Regional Development (EFRE). The authors also thank Dr. O. Ibidapo-obe for helpful discussion. Open access funding enabled and organized by Projekt DEAL.
Funding
This work was financially supported by the DFG-funded Collaborative Research Centre PolyTarget (Project-ID: 316213987-SFB 1278, A05). Tony Bruns was supported by the German Research Foundation (CRC1382, Project-ID 403224013). Johannes C. Brendel further thanks the DFG for funding within the Emmy-Noether Programme (Project-ID: 358263073). Furthermore, the authors thank Stephanie Höppener for her support by performing the CryoTEM investigations at the electron microscopy facilities of the Jena Center for Soft Matter (JCSM), which were purchased with grants from the DFG and the European funds for Regional Development (EFRE). The authors also thank Dr. O. Ibidapo-obe for helpful discussion. Open access funding enabled and organized by Projekt DEAL. This work was financially supported by the DFG‐funded Collaborative Research Centre PolyTarget (Project‐ID: 316213987‐SFB 1278, A05). Tony Bruns was supported by the German Research Foundation (CRC1382, Project‐ID 403224013). Johannes C. Brendel further thanks the DFG for funding within the Emmy‐Noether Programme (Project‐ID: 358263073). Furthermore, the authors thank Stephanie Höppener for her support by performing the CryoTEM investigations at the electron microscopy facilities of the Jena Center for Soft Matter (JCSM), which were purchased with grants from the DFG and the European funds for Regional Development (EFRE). The authors also thank Dr. O. Ibidapo‐obe for helpful discussion.
Keywords
- controlled release
- PISA
- RAFT polymerization
- reactive oxygen species
- smart delivery
- Reactive Oxygen Species/metabolism
- Inflammatory Bowel Diseases/metabolism
- Humans
- Micelles
- Monocytes/metabolism
- Polymers/chemistry