Role of biomaterials and controlled architecture on Tendon/Ligament Repair and Regeneration

Young Jung No, Miguel Castilho, Yogambha Ramaswamy, Hala Zreiqat (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

119 Citations (Scopus)

Abstract

Engineering synthetic scaffolds to repair and regenerate ruptured native tendon and ligament (T/L) tissues is a significant engineering challenge due to the need to satisfy both the unique biological and biomechanical properties of these tissues. Long‐term clinical outcomes of synthetic scaffolds relying solely on high uniaxial tensile strength are poor with high rates of implant rupture and synovitis. Ideal biomaterials for T/L repair and regeneration need to possess the appropriate biological and biomechanical properties necessary for the successful repair and regeneration of ruptured tendon and ligament tissues.
Original languageEnglish
Article number1904511
JournalAdvanced Materials
Volume32
Issue number18
Early online date9 Dec 2019
DOIs
Publication statusPublished - May 2020

Funding

The authors gratefully acknowledge the following agencies for their financial support: Australian Research Council Training Centre for Innovative Bioengineering, the Australian National Health and Medical Research Council, Radcliffe Institute for Advanced Study at Harvard University, the Rebecca L. Cooper Medical Research Foundation, the strategic alliance University Medical Center Utrecht—Technical University Eindhoven and the partners of Regenerative Medicine Crossing Borders ( https://www.regmedxb.com ) and powered by Health‐Holland, Top Sector Life Sciences & Health. The authors gratefully acknowledge the following agencies for their financial support: Australian Research Council Training Centre for Innovative Bioengineering, the Australian National Health and Medical Research Council, Radcliffe Institute for Advanced Study at Harvard University, the Rebecca L. Cooper Medical Research Foundation, the strategic alliance University Medical Center Utrecht—Technical University Eindhoven and the partners of Regenerative Medicine Crossing Borders (https://www.regmedxb.com) and powered by Health-Holland, Top Sector Life Sciences & Health.

FundersFunder number
Australian Research Council Training Centre for Innovative Bioengineering
Health~Holland
Regenerative Medicine Crossing Borders
Universitair Medisch Centrum Utrecht
Harvard University
Health~Holland
National Health and Medical Research Council
Rebecca L. Cooper Medical Research Foundation

    Keywords

    • fiber architecture
    • fiber-reinforced hydrogel
    • hydrogel
    • Ligaments, Articular/injuries
    • synthetic biomaterials
    • tendons
    • ligaments

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