Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts

Kasia Trzcionkowska (Corresponding author), Floris Groenendaal, Peter Andriessen, Peter H. Dijk, Frank A.M. van den Dungen, Jacqueline L. van Hillegersberg, Sanne Koole, René F. Kornelisse, Elke van Westering-Kroon, Jeanette S. von Lindern, Clemens B. Meijssen, Frank A.B.A. Schuerman, Katerina Steiner, Minke W.G. van Tuyl, Ruben S.G.M. Witlox, Nicoline E. Schalij-Delfos, Jacqueline U.M. Termote

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Abstract

INTRODUCTION: Retinopathy of prematurity (ROP) remains an important cause for preventable blindness. Aside from gestational age (GA) and birth weight, risk factor assessment can be important for determination of infants at risk of (severe) ROP.

METHODS: Prospective, multivariable risk-analysis study (NEDROP-2) was conducted, including all infants born in 2017 in the Netherlands considered eligible for ROP screening by pediatricians. Ophthalmologists provided data of screened infants, which were combined with risk factors from the national perinatal database (Perined). Clinical data and potential risk factors were compared to the first national ROP inventory (NEDROP-1, 2009). During the second period, more strict risk factor-based screening inclusion criteria were applied.

RESULTS: Of 1,287 eligible infants, 933 (72.5%) were screened for ROP and matched with the Perined data. Any ROP was found in 264 infants (28.3% of screened population, 2009: 21.9%) and severe ROP (sROP) (stage ≥3) in 41 infants (4.4%, 2009: 2.1%). The risk for any ROP is decreased with a higher GA (odds ratio [OR] 0.59 and 95% confidence interval [CI] 0.54-0.66) and increased for small for GA (SGA) (1.73, 1.11-2.62), mechanical ventilation >7 days (2.13, 1.35-3.37) and postnatal corticosteroids (2.57, 1.44-4.66). For sROP, significant factors were GA (OR 0.37 and CI 0.27-0.50), SGA (OR 5.65 and CI 2.17-14.92), postnatal corticosteroids (OR 3.81 and CI 1.72-8.40), and perforated necrotizing enterocolitis (OR 7.55 and CI 2.29-24.48).

CONCLUSION: In the Netherlands, sROP was diagnosed more frequently since 2009. No new risk factors for ROP were determined in the present study, apart from those already included in the current screening guideline.

Original languageEnglish
Pages (from-to)462-469
Number of pages8
JournalNeonatology
Volume118
Issue number4
Early online date22 Jul 2021
DOIs
Publication statusPublished - 1 Aug 2021

Bibliographical note

© 2021 The Author(s) Published by S. Karger AG, Basel.

Keywords

  • Prematurity and screening
  • Retinopathy of prematurity

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