@inbook{b5bc3b66c75f4d41a4456690419590e0,
title = "Ring-opening of ω-substituted lactones by Novozym 435 : selectivity issues and application to iterative tandem catalysis",
abstract = "The enantioselectivity of the Novozym{\textregistered} 435 catalysed ring-opening of lactones is related to the conformation of the ester: cisoid lactones show S-selectivity or no selectivity while transoid lactones show a pronounced R-selectivity. The inability of Novozym 435 to polymerise 6-MeCL stems from its opposing selectivities for the alcohol and acyl moiety. By combining Novozym 435 with a racemisation catalyst, unreactive terminal alcohols in the S-configuration can be turned into reactive terminal alcohols of the R-configuration which can propagate. Combining 2 different catalysts that work together to accomplish propagation, also referred to as iterative tandem catalysis, is an elegant approach to convert a racemic monomer quantitatively into a homochiral polymer.",
author = "A.R.A. Palmans and {As, van}, B.A.C. and {Buijtenen, van}, J. and E.W. Meijer",
year = "2008",
doi = "10.1021/bk-2008-0999.ch015",
language = "English",
isbn = "978-0-8412-6970-5",
series = "ACS symposium series",
publisher = "American Chemical Society",
pages = "230--244",
editor = "H.N. Cheng and R.A. Gross",
booktitle = "Polymer biocatalysis and biomaterials II",
address = "United States",
}