Clinical tractography is a challenging problem in diffusion tensor imaging (DTI) due to persistent validation issues. Geodesic tractography, based on a shortest path principle, is conceptually appealing, but has not produced convincing results so far. A major weakness is its rigidity with respect to candidate tracts it is capable of producing given a pair of endpoints, showing a tendency to produce false positives (such as shortcuts) and false negatives (e.g. if a shortcut supplants the correct solution). We propose a new geodesic paradigm that appears to overcome these problems, making a step towards semi-automatic clinical use. To this end we couple the DTI tensor field to a family of Riemannian metrics, governed by control parameters. In practice these parameters may allow for edits by an expert through manual selection among multiple tract suggestions, or for bringing in a priori knowledge. In this paper, however, we consider an automatic, evidence-driven procedure to determine optimal controls and corresponding tentative tracts, and illustrate the role of edits to remediate erroneous defaults.
|Title of host publication||Anisotropy Across Fields and Scales|
|Editors||Evren Özarslan, Thomas Schultz, Eugene Zhang, Andrea Fuster|
|Place of Publication||Cham|
|Publication status||Published - 11 Feb 2021|
|Name||Mathematics and Visualization|
- Diffusion Tensor Imaging
- Geodesic Tractography