Rhodium-catalysed hydroformylation of N-(2-propenyl)-ß-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides

S. Dekeukeleire; M.W.A. D'hooghe; C. Müller; D. Vogt; N. De Kimpe

doi:10.1039/c0nj00146e

Rhodium-catalysed hydroformylation of N-(2-propenyl)-ß-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides

S. Dekeukeleire, M.W.A. D'hooghe, C. Müller, D. Vogt, N. De Kimpe

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Biologically relevant functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides have been prepared in a two-step approach starting from N-(2-propenyl)--lactams, involving initial rhodium-catalysed hydroformylation followed by subjection of the obtained aldehydes to Staudinger reaction conditions after initial imination.

Original language	English
Pages (from-to)	1079-1083
Number of pages	4
Journal	New Journal of Chemistry
Volume	34
DOIs	https://doi.org/10.1039/c0nj00146e
Publication status	Published - 2010

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title = "Rhodium-catalysed hydroformylation of N-(2-propenyl)-{\ss}-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides",

abstract = "Biologically relevant functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides have been prepared in a two-step approach starting from N-(2-propenyl)--lactams, involving initial rhodium-catalysed hydroformylation followed by subjection of the obtained aldehydes to Staudinger reaction conditions after initial imination.",

author = "S. Dekeukeleire and M.W.A. D'hooghe and C. M{\"u}ller and D. Vogt and {De Kimpe}, N.",

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journal = "New Journal of Chemistry",

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T1 - Rhodium-catalysed hydroformylation of N-(2-propenyl)-ß-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides

AU - Dekeukeleire, S.

AU - D'hooghe, M.W.A.

AU - Müller, C.

AU - Vogt, D.

AU - De Kimpe, N.

PY - 2010

Y1 - 2010

N2 - Biologically relevant functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides have been prepared in a two-step approach starting from N-(2-propenyl)--lactams, involving initial rhodium-catalysed hydroformylation followed by subjection of the obtained aldehydes to Staudinger reaction conditions after initial imination.

AB - Biologically relevant functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides have been prepared in a two-step approach starting from N-(2-propenyl)--lactams, involving initial rhodium-catalysed hydroformylation followed by subjection of the obtained aldehydes to Staudinger reaction conditions after initial imination.

U2 - 10.1039/c0nj00146e

DO - 10.1039/c0nj00146e

M3 - Article

SN - 1144-0546

VL - 34

SP - 1079

EP - 1083

JO - New Journal of Chemistry

JF - New Journal of Chemistry

ER -

Rhodium-catalysed hydroformylation of N-(2-propenyl)-ß-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides

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