Rhodium-catalysed hydroformylation of N-(2-propenyl)-ß-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides

S. Dekeukeleire, M.W.A. D'hooghe, C. Müller, D. Vogt, N. De Kimpe

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

Biologically relevant functionalised N-[4-(2-oxoazetidin-1-yl)-but-1-enyl]acetamides have been prepared in a two-step approach starting from N-(2-propenyl)--lactams, involving initial rhodium-catalysed hydroformylation followed by subjection of the obtained aldehydes to Staudinger reaction conditions after initial imination.
Original languageEnglish
Pages (from-to)1079-1083
Number of pages4
JournalNew Journal of Chemistry
Volume34
DOIs
Publication statusPublished - 2010

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