Reversibly self-assembled pH-responsive PEG-p(CL-g-TMC) polymersomes

Pascal L.W. Welzen, Sydney W. Martinez Ciriano, Shoupeng Cao, Alexander F. Mason, Imke A.B. Welzen-Pijpers, Jan C.M. van Hest (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
94 Downloads (Pure)


Polymersomes have gained much interest within the biomedical field as drug delivery systems due to their ability to transport and protect cargo from the harsh environment inside the body. For an improved drug efficacy, control over cargo release is however also an important factor to take into account. An often employed method is to incorporate pH sensitive groups in the vesicle membrane, which induce disassembly and content release when the particles have reached a target site in the body with the appropriate pH, such as the acidic microenvironment of tumor tissue or the endosome. In this paper, biodegradable poly(ethylene glycol)-poly(caprolactone-gradient-trimethylene carbonate)-based polymeric vesicles have been developed with disassembly features at mild acidic conditions. Modifying the polymer backbone with imidazole moieties results in vesicle disassembly upon protonation due to the lowered pH. Furthermore, upon increasing the pH efficient re-assembly into vesicles is observed due to the switchable amphiphilic nature of the polymer. When this re-assembly process is conducted in presence of cargo, enhanced encapsulation is achieved. Furthermore, the potency of the polymeric system for future biomedical applications such as adjuvant delivery is demonstrated.

Original languageEnglish
Pages (from-to)1241-1252
Number of pages12
JournalJournal of Polymer Science
Issue number12
Publication statusPublished - 15 Jun 2021


This research was funded by the Dutch Ministry of Education, Culture and Science (Gravitation Program 024.001.035) and the TTW Perspective program BacVactory.

FundersFunder number
Ministerie van Onderwijs, Cultuur en Wetenschap024.001.035


    • biodegradable
    • encapsulation
    • pH-responsive
    • polymersome
    • reversible


    Dive into the research topics of 'Reversibly self-assembled pH-responsive PEG-p(CL-g-TMC) polymersomes'. Together they form a unique fingerprint.

    Cite this