Responsive Peptide Nanofibers with Theranostic and Prognostic Capacity

Bingbing Sun; Xiaoping Guo; Mei Feng; Shoupeng Cao; Haowen Yang; Hanglong Wu; Marleen H.M.E. van Stevendaal; Roy A.J.F. Oerlemans; Jinning Liang; Yiqiang Ouyang; Jan C.M. van Hest

doi:10.1002/ange.202208732

Responsive Peptide Nanofibers with Theranostic and Prognostic Capacity

Bingbing Sun, Xiaoping Guo, Mei Feng, Shoupeng Cao, Haowen Yang, Hanglong Wu, Marleen H.M.E. van Stevendaal, Roy A.J.F. Oerlemans, Jinning Liang, Yiqiang Ouyang (Corresponding author), Jan C.M. van Hest (Corresponding author)

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Abstract

Photodynamic therapy (PDT) is a highly promising therapeutic modality for cancer treatment. The development of stimuli-responsive photosensitizer nanomaterials overcomes certain limitations in clinical PDT. Herein, we report the rational design of a highly sensitive PEGylated photosensitizer-peptide nanofiber (termed PHHPEG₆ NF) that selectively aggregates in the acidic tumor and lysosomal microenvironment. These nanofibers exhibit acid-induced enhanced singlet oxygen generation, cellular uptake, and PDT efficacy in vitro, as well as fast tumor accumulation, long-term tumor imaging capacity and effective PDT in vivo. Moreover, based on the prolonged presence of the fluorescent signal at the tumor site, we demonstrate that PHHPEG₆ NFs can also be applied for prognostic monitoring of the efficacy of PDT in vivo, which would potentially guide cancer treatment. Therefore, these multifunctional PHHPEG₆ NFs allow control over the entire PDT process, from visualization of photosensitizer accumulation, via actual PDT to the assessment of the efficacy of the treatment.

Original language	English
Article number	e202208732
Number of pages	9
Journal	Angewandte Chemie
Volume	134
Issue number	38
DOIs	https://doi.org/10.1002/ange.202208732
Publication status	Published - 19 Sept 2022

Bibliographical note

Funding Information:
We acknowledge financial support from NWO (Spinoza award SPI 71‐259) and the Eurotech Postdoc Programme, under the Marie Skłodowska‐Curie grant agreement No 754462. All animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals and were approved by the Animal Care & Welfare Committee of Guangxi Medical University in compliance with Chinese law for experimental animals with an approval number of 202111007.

Keywords

Long-Term Tumor Retention
Nanofibers
Peptides
Photodynamic Therapy
Self-Assembly

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Responsive Peptide Nanofibers with Theranostic and Prognostic Capacity",

abstract = "Photodynamic therapy (PDT) is a highly promising therapeutic modality for cancer treatment. The development of stimuli-responsive photosensitizer nanomaterials overcomes certain limitations in clinical PDT. Herein, we report the rational design of a highly sensitive PEGylated photosensitizer-peptide nanofiber (termed PHHPEG6 NF) that selectively aggregates in the acidic tumor and lysosomal microenvironment. These nanofibers exhibit acid-induced enhanced singlet oxygen generation, cellular uptake, and PDT efficacy in vitro, as well as fast tumor accumulation, long-term tumor imaging capacity and effective PDT in vivo. Moreover, based on the prolonged presence of the fluorescent signal at the tumor site, we demonstrate that PHHPEG6 NFs can also be applied for prognostic monitoring of the efficacy of PDT in vivo, which would potentially guide cancer treatment. Therefore, these multifunctional PHHPEG6 NFs allow control over the entire PDT process, from visualization of photosensitizer accumulation, via actual PDT to the assessment of the efficacy of the treatment.",

keywords = "Long-Term Tumor Retention, Nanofibers, Peptides, Photodynamic Therapy, Self-Assembly",

author = "Bingbing Sun and Xiaoping Guo and Mei Feng and Shoupeng Cao and Haowen Yang and Hanglong Wu and {van Stevendaal}, {Marleen H.M.E.} and Oerlemans, {Roy A.J.F.} and Jinning Liang and Yiqiang Ouyang and {van Hest}, {Jan C.M.}",

note = "Funding Information: We acknowledge financial support from NWO (Spinoza award SPI 71‐259) and the Eurotech Postdoc Programme, under the Marie Sk{\l}odowska‐Curie grant agreement No 754462. All animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals and were approved by the Animal Care & Welfare Committee of Guangxi Medical University in compliance with Chinese law for experimental animals with an approval number of 202111007. ",

year = "2022",

month = sep,

day = "19",

doi = "10.1002/ange.202208732",

language = "English",

volume = "134",

journal = "Angewandte Chemie",

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TY - JOUR

T1 - Responsive Peptide Nanofibers with Theranostic and Prognostic Capacity

AU - Sun, Bingbing

AU - Guo, Xiaoping

AU - Feng, Mei

AU - Cao, Shoupeng

AU - Yang, Haowen

AU - Wu, Hanglong

AU - van Stevendaal, Marleen H.M.E.

AU - Oerlemans, Roy A.J.F.

AU - Liang, Jinning

AU - Ouyang, Yiqiang

AU - van Hest, Jan C.M.

N1 - Funding Information: We acknowledge financial support from NWO (Spinoza award SPI 71‐259) and the Eurotech Postdoc Programme, under the Marie Skłodowska‐Curie grant agreement No 754462. All animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals and were approved by the Animal Care & Welfare Committee of Guangxi Medical University in compliance with Chinese law for experimental animals with an approval number of 202111007.

PY - 2022/9/19

Y1 - 2022/9/19

N2 - Photodynamic therapy (PDT) is a highly promising therapeutic modality for cancer treatment. The development of stimuli-responsive photosensitizer nanomaterials overcomes certain limitations in clinical PDT. Herein, we report the rational design of a highly sensitive PEGylated photosensitizer-peptide nanofiber (termed PHHPEG6 NF) that selectively aggregates in the acidic tumor and lysosomal microenvironment. These nanofibers exhibit acid-induced enhanced singlet oxygen generation, cellular uptake, and PDT efficacy in vitro, as well as fast tumor accumulation, long-term tumor imaging capacity and effective PDT in vivo. Moreover, based on the prolonged presence of the fluorescent signal at the tumor site, we demonstrate that PHHPEG6 NFs can also be applied for prognostic monitoring of the efficacy of PDT in vivo, which would potentially guide cancer treatment. Therefore, these multifunctional PHHPEG6 NFs allow control over the entire PDT process, from visualization of photosensitizer accumulation, via actual PDT to the assessment of the efficacy of the treatment.

AB - Photodynamic therapy (PDT) is a highly promising therapeutic modality for cancer treatment. The development of stimuli-responsive photosensitizer nanomaterials overcomes certain limitations in clinical PDT. Herein, we report the rational design of a highly sensitive PEGylated photosensitizer-peptide nanofiber (termed PHHPEG6 NF) that selectively aggregates in the acidic tumor and lysosomal microenvironment. These nanofibers exhibit acid-induced enhanced singlet oxygen generation, cellular uptake, and PDT efficacy in vitro, as well as fast tumor accumulation, long-term tumor imaging capacity and effective PDT in vivo. Moreover, based on the prolonged presence of the fluorescent signal at the tumor site, we demonstrate that PHHPEG6 NFs can also be applied for prognostic monitoring of the efficacy of PDT in vivo, which would potentially guide cancer treatment. Therefore, these multifunctional PHHPEG6 NFs allow control over the entire PDT process, from visualization of photosensitizer accumulation, via actual PDT to the assessment of the efficacy of the treatment.

KW - Long-Term Tumor Retention

KW - Nanofibers

KW - Peptides

KW - Photodynamic Therapy

KW - Self-Assembly

U2 - 10.1002/ange.202208732

DO - 10.1002/ange.202208732

M3 - Article

SN - 0044-8249

VL - 134

JO - Angewandte Chemie

JF - Angewandte Chemie

IS - 38

M1 - e202208732

ER -

Responsive Peptide Nanofibers with Theranostic and Prognostic Capacity

Abstract

Bibliographical note

Keywords

UN SDGs

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