Repetitive transcranial magnetic stimulation for the treatment of refractory epilepsy

S. Carrette, P. Boon, C Dekeyser, D.C.W. Klooster, E.C.B. Carrette, A. Meurs, R. Raedt, C. Baeken, C. Vanhove, A.P. Aldenkamp, K.E.J. Vonck

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Abstract

Introduction: Repetitive transcranial magnetic stimulation (rTMS) is an established non-invasive neurostimulation technique that is able to induce neuromodulatory effects outlasting the duration of the stimulation train. The cortical excitability disturbance in epilepsy provides a rationale for investigating the efficacy of low-frequency rTMS as a treatment for epilepsy patients. Sofar clinical trials in epilepsy patients have shown conflicting results ranging from ineffective to very effective.
Areas covered: This manuscript provides an overview of the performed studies, retrieved from a PubMed search, and a critical appraisal of their results. A number of conclusions are drawn and potential optimization strategies are discussed.
Expert commentary: Although the therapeutic efficacy of rTMS in refractory epilepsy has not yet been established, the non-invasiveness of the technique warrants further investigation of rTMS as a treatment for epilepsy.
LanguageEnglish
Pages1093-1110
JournalExpert Review of Neurotherapeutics
Volume16
Issue number9
DOIs
StatePublished - Sep 2016

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Transcranial Magnetic Stimulation
Epilepsy
Therapeutics
PubMed
Clinical Trials

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Carrette, S. ; Boon, P. ; Dekeyser, C ; Klooster, D.C.W. ; Carrette, E.C.B. ; Meurs, A. ; Raedt, R. ; Baeken, C. ; Vanhove, C. ; Aldenkamp, A.P. ; Vonck, K.E.J./ Repetitive transcranial magnetic stimulation for the treatment of refractory epilepsy. In: Expert Review of Neurotherapeutics. 2016 ; Vol. 16, No. 9. pp. 1093-1110
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Carrette, S, Boon, P, Dekeyser, C, Klooster, DCW, Carrette, ECB, Meurs, A, Raedt, R, Baeken, C, Vanhove, C, Aldenkamp, AP & Vonck, KEJ 2016, 'Repetitive transcranial magnetic stimulation for the treatment of refractory epilepsy' Expert Review of Neurotherapeutics, vol. 16, no. 9, pp. 1093-1110. DOI: 10.1080/14737175.2016.1197119

Repetitive transcranial magnetic stimulation for the treatment of refractory epilepsy. / Carrette, S.; Boon, P.; Dekeyser, C; Klooster, D.C.W.; Carrette, E.C.B.; Meurs, A.; Raedt, R.; Baeken, C.; Vanhove, C.; Aldenkamp, A.P.; Vonck, K.E.J.

In: Expert Review of Neurotherapeutics, Vol. 16, No. 9, 09.2016, p. 1093-1110.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Boon,P.

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AU - Klooster,D.C.W.

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AU - Meurs,A.

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AU - Vonck,K.E.J.

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