Refining the design of diblock elastin-like polypeptides for self-assembly into nanoparticles

Michèle Dai, Evangelos Georgilis, Guillaume Goudounet, Bertrand Garbay, Jan Pille, Jan C.M. van Hest, Xavier Schultze, Elisabeth Garanger (Corresponding author), Sébastien Lecommandoux (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Diblock copolymers based-on elastin-like polypeptide (ELP) have the potential to undergo specific phase transitions when thermally stimulated. This ability is especially suitable to form carriers, micellar structures for instance, for delivering active cargo molecules. Here, we report the design and study of an ELP diblock library based on ELP-[M1V3-i]-[I-j]. First, ELP-[M1V3-i]-[I-j] (i = 20, 40, 60; j = 20, 90) that showed a similar self-assembly propensity (unimer-to-aggregate transition) as their related monoblocks ELP-[M1V3-i] and ELP-[I-j]. By selectively oxidizing methionines of ELP-[M1V3-i] within the different diblocks structures, we have been able to access a thermal phase transition with three distinct regimes (unimers, micelles, aggregates) characteristic of well-defined ELP diblocks.

Original languageEnglish
Article number1470
Number of pages17
JournalPolymers
Volume13
Issue number9
DOIs
Publication statusPublished - 1 May 2021

Bibliographical note

Funding Information:
Funding: This work was supported by a CIFRE grant to M.D. from ANRT and by the European Union’s Horizon 2020 research and innovation program Marie Skłodowska-Curie Innovative Training Networks (ITN) under grant No. 676137 (NANOMED project).

Keywords

  • Elastin-like polypeptides
  • Methionine oxidation
  • Nanoparticles
  • Self-assembly
  • Thermoresponsiveness

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