Reengineering of a fluorescent zinc sensor yields the first genetically encoded cadnium probe

J.L. Vinkenborg; S.M.J. Duijnhoven, van; M. Merkx

doi:10.1039/c1cc14944j

Reengineering of a fluorescent zinc sensor yields the first genetically encoded cadnium probe

J.L. Vinkenborg, S.M.J. Duijnhoven, van, M. Merkx

Research output: Contribution to journal › Article › Academic › peer-review

33 Citations (Scopus)

Abstract

Introduction of a (Cys)4 metal binding site at the dimerization interface of two fluorescent protein domains yields a chelating FRET sensor protein that shows a 2500-fold selectivity for Cd2+ over Zn2+ by taking advantage of their different ionic radii.

Original language	English
Pages (from-to)	11879-11881
Journal	Chemical Communications, ChemComm
Volume	47
Issue number	43
DOIs	https://doi.org/10.1039/c1cc14944j
Publication status	Published - 2011

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title = "Reengineering of a fluorescent zinc sensor yields the first genetically encoded cadnium probe",

abstract = "Introduction of a (Cys)4 metal binding site at the dimerization interface of two fluorescent protein domains yields a chelating FRET sensor protein that shows a 2500-fold selectivity for Cd2+ over Zn2+ by taking advantage of their different ionic radii.",

author = "J.L. Vinkenborg and \{Duijnhoven, van\}, S.M.J. and M. Merkx",

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SP - 11879

EP - 11881

JO - Chemical Communications, ChemComm

JF - Chemical Communications, ChemComm

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Reengineering of a fluorescent zinc sensor yields the first genetically encoded cadnium probe

Abstract

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