Reengineering of a fluorescent zinc sensor yields the first genetically encoded cadnium probe

J.L. Vinkenborg, S.M.J. Duijnhoven, van, M. Merkx

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Abstract

Introduction of a (Cys)4 metal binding site at the dimerization interface of two fluorescent protein domains yields a chelating FRET sensor protein that shows a 2500-fold selectivity for Cd2+ over Zn2+ by taking advantage of their different ionic radii.
Original languageEnglish
Pages (from-to)11879-11881
JournalChemical Communications
Volume47
Issue number43
DOIs
Publication statusPublished - 2011

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