Reducing distortions in echo-planar breast imaging at ultrahigh field with high-resolution off-resonance maps

Michael J. van Rijssel (Corresponding author), Frank Zijlstra, Peter R. Seevinck, Peter R. Luijten, Kenneth G.A. Gilhuijs, Dennis W.J. Klomp, Josien P.W. Pluim

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Abstract

Purpose: DWI is a promising modality in breast MRI, but its clinical acceptance is slow. Analysis of DWI is hampered by geometric distortion artifacts, which are caused by off-resonant spins in combination with the low phase-encoding bandwidth of the EPI sequence used. Existing correction methods assume smooth off-resonance fields, which we show to be invalid in the human breast, where high discontinuities arise at tissue interfaces. Methods: We developed a distortion correction method that incorporates high-resolution off-resonance maps to better solve for severe distortions at tissue interfaces. The method was evaluated quantitatively both ex vivo in a porcine tissue phantom and in vivo in 5 healthy volunteers. The added value of high-resolution off-resonance maps was tested using a Wilcoxon signed rank test comparing the quantitative results obtained with a low-resolution off-resonance map with those obtained with a high-resolution map. Results: Distortion correction using low-resolution off-resonance maps corrected most of the distortions, as expected. Still, all quantitative comparison metrics showed increased conformity between the corrected EPI images and a high-bandwidth reference scan for both the ex vivo and in vivo experiments. All metrics showed a significant improvement when a high-resolution off-resonance map was used (P < 0.05), in particular at tissue boundaries. Conclusion: The use of off-resonance maps of a resolution higher than EPI scans significantly improves upon existing distortion correction techniques, specifically by superior correction at glandular tissue boundaries.

Original languageEnglish
Pages (from-to)425-435
Number of pages11
JournalMagnetic Resonance in Medicine
Volume82
Issue number1
Early online date1 Mar 2019
DOIs
Publication statusPublished - Jul 2019

Keywords

  • 7T
  • B mapping
  • breast
  • diffusion-weighted imaging
  • distortion correction
  • echo-planar imaging
  • off-resonance

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    van Rijssel, M. J., Zijlstra, F., Seevinck, P. R., Luijten, P. R., Gilhuijs, K. G. A., Klomp, D. W. J., & Pluim, J. P. W. (2019). Reducing distortions in echo-planar breast imaging at ultrahigh field with high-resolution off-resonance maps. Magnetic Resonance in Medicine, 82(1), 425-435. https://doi.org/10.1002/mrm.27701