Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies

Roy van der Meel; William M. Gallagher; Sabrina Oliveira; Aisling E. O'Connor; Raymond M. Schiffelers; Annette T. Byrne

doi:10.1016/j.drudis.2009.12.003

Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies

Roy van der Meel
, William M. Gallagher
, Sabrina Oliveira
, Aisling E. O'Connor
, Raymond M. Schiffelers
, Annette T. Byrne

Research output: Contribution to journal › Review article › peer-review

43 Citations (Scopus)

Abstract

Molecular imaging is the visualization, characterization and measurement of biological processes at the molecular and cellular level. In oncology, molecular imaging approaches can be directly applied as translational biomarkers of disease progression. In this article, selected imaging modalities are discussed with respect to this role. Recent studies focusing on emerging imaging biomarkers and new developments in the field are highlighted. Importantly, because ex vivo or tissue-based imaging now represents an important tool in the discovery and validation of oncology biomarkers, special attention is given to this resurgent field.

Original language	English
Pages (from-to)	102-114
Number of pages	13
Journal	Drug Discovery Today
Volume	15
Issue number	3-4
DOIs	https://doi.org/10.1016/j.drudis.2009.12.003
Publication status	Published - 1 Feb 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Biomarkers, Tumor
Disease Progression
Humans
Molecular Imaging/methods
Neoplasms/diagnosis
Radionuclide Imaging
Translational Medical Research/methods
Validation Studies as Topic

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10.1016/j.drudis.2009.12.003

Cite this

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title = "Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies",

abstract = "Molecular imaging is the visualization, characterization and measurement of biological processes at the molecular and cellular level. In oncology, molecular imaging approaches can be directly applied as translational biomarkers of disease progression. In this article, selected imaging modalities are discussed with respect to this role. Recent studies focusing on emerging imaging biomarkers and new developments in the field are highlighted. Importantly, because ex vivo or tissue-based imaging now represents an important tool in the discovery and validation of oncology biomarkers, special attention is given to this resurgent field.",

keywords = "Animals, Biomarkers, Tumor, Disease Progression, Humans, Molecular Imaging/methods, Neoplasms/diagnosis, Radionuclide Imaging, Translational Medical Research/methods, Validation Studies as Topic",

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year = "2010",

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doi = "10.1016/j.drudis.2009.12.003",

language = "English",

volume = "15",

pages = "102--114",

journal = "Drug Discovery Today",

issn = "1359-6446",

publisher = "Elsevier",

number = "3-4",

}

TY - JOUR

T1 - Recent advances in molecular imaging biomarkers in cancer

T2 - application of bench to bedside technologies

AU - van der Meel, Roy

AU - Gallagher, William M.

AU - Oliveira, Sabrina

AU - O'Connor, Aisling E.

AU - Schiffelers, Raymond M.

AU - Byrne, Annette T.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Molecular imaging is the visualization, characterization and measurement of biological processes at the molecular and cellular level. In oncology, molecular imaging approaches can be directly applied as translational biomarkers of disease progression. In this article, selected imaging modalities are discussed with respect to this role. Recent studies focusing on emerging imaging biomarkers and new developments in the field are highlighted. Importantly, because ex vivo or tissue-based imaging now represents an important tool in the discovery and validation of oncology biomarkers, special attention is given to this resurgent field.

AB - Molecular imaging is the visualization, characterization and measurement of biological processes at the molecular and cellular level. In oncology, molecular imaging approaches can be directly applied as translational biomarkers of disease progression. In this article, selected imaging modalities are discussed with respect to this role. Recent studies focusing on emerging imaging biomarkers and new developments in the field are highlighted. Importantly, because ex vivo or tissue-based imaging now represents an important tool in the discovery and validation of oncology biomarkers, special attention is given to this resurgent field.

KW - Animals

KW - Biomarkers, Tumor

KW - Disease Progression

KW - Humans

KW - Molecular Imaging/methods

KW - Neoplasms/diagnosis

KW - Radionuclide Imaging

KW - Translational Medical Research/methods

KW - Validation Studies as Topic

UR - https://www.scopus.com/pages/publications/75449108814

U2 - 10.1016/j.drudis.2009.12.003

DO - 10.1016/j.drudis.2009.12.003

M3 - Review article

C2 - 20035896

SN - 1359-6446

VL - 15

SP - 102

EP - 114

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 3-4

ER -

Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies

Abstract

UN SDGs

Keywords

Access to Document

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